Neural, Behavioral and Physiological Correlates of Feeding in Humans
The overarching goal of this project is to understand how nicotine addiction interacts with feeding behaviors and brain representation of food reward. The current proposal is part of a larger effort to begin a program of research to elucidate similarities and differences in perception of, and behavioral and neural response to, food and cigarette aromas as a function of 1) smoking status (smokers, ex-smokers who do gain weight, ex-smokers who do not gain weight, non-smokers), 2) internal state (hungry, full), and 3) cigarette deprivation (acute, chronic). A general hypothesis is that there are overlapping neural mechanisms governing food reward and cigarette reward in smokers and that this overlap includes incentive salience encoding.
Magnetic Resonance Imaging, Functional
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Neural, Behavioral and Physiological Correlates of Feeding in Humans|
- fMRI w/ taste and smell stimuli [ Time Frame: 1-2 hours ] [ Designated as safety issue: No ]Subjects will be scanned on a 3T Trio magnet while tasting and smelling various food and non-food substances. Our primary outcome measure will be differential brain responses to taste and smell stimuli as a function of group (smokers vs. nonsmokers).
Biospecimen Retention: Samples With DNA
saliva samples were obtained and are stored using a coded ID in a secure part of our facility
|Study Start Date:||June 2005|
|Study Completion Date:||July 2009|
|Primary Completion Date:||July 2009 (Final data collection date for primary outcome measure)|
Individuals that are right handed, and not claustrophobic were recruited. This same group was used for the smoking-group and refrain from smoking was evaluated by CO2 evaluation. To be classified as smokers, they had to report smoking 3-10 cigarettes daily for at least the last year and have a carbon monoxide reading of CO >10 ppm.
Healthy individuals meeting the inclusion criteria who claim to not smoke. This is confirmed w/ CO testing.
Weight gain frequently follows smoking cessation. Fear of weight gain is cited as a key reason not to quit and actual weight gain is a primary reason for relapse, especially among women. Although the causes of weight gain following smoking cessation are complex, increased caloric intake is recognized as one of the primary sources. One explanation for increased caloric intake is that, there are common neural mechanisms for food and cigarette reward and hence food reward can substitute for cigarette reward and vice versa. An alternative explanation for weight gain following smoking cessation is that there is an overall decrease in brain reward function during nicotine withdrawal, which leads to a decrease in the reward value of food and consequent increase in intake to maintain the total amount of reward obtained by food. The success of the proposed studies relies upon our ability to deliver odorants in the fMRI scanner and to measure neural activation in regions such as the amygdala, which are susceptible to inhomogeneity artifacts.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01665560
|United States, Connecticut|
|John B Pierce Laboratory|
|New Haven, Connecticut, United States, 06519|
|Principal Investigator:||Dana M Small, PhD||Yale & John B Pierce Laboratory|