ADHD Electrophysiological Subtypes and Implications in Transcranial Direct-current Stimulation (tdcs&adhd)
In the present study, we aim to examine whether transcranial direct-current stimulation (tDCS) generated excitability changes induce modifications of functional cortical architecture in Attention Deficit Hyperactivity Disorder (ADHD) patients. To achieve this, we used an event-related potential (ERP) analysis based on 20 channel EEG recordings in ADHD subjects before and after bipolar tDCS-anode stimulation over F3, during resting state and measure clinical scores and visual CPT tasks changes. Time courses and topography of independent component visual ERPs were compared before and after tDCS.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Implications of Electrophysiological ADHD Endophenotypes to Predict Response to Transcranial Direct-Current Stimulation|
- Observable behaviour [ Time Frame: 3 months ] [ Designated as safety issue: No ]The primary outcome was change in score on the QEEG Rating Scale (AMEN questionnaire), which assesses behaviour. Assessments were made at baseline (before stimulation), after the 10-12 days of stimulation, and at 1 and 3 months after stimulation.
- Event-related potentials (ERPs) [ Time Frame: 3 months ] [ Designated as safety issue: No ]ERPs to the GO/NOGO task will be examined for changes as a result of treatment. Assessments were made at baseline (before stimulation), after the 10-12 days of stimulation, and at 1 and 3 months after stimulation.
|Study Start Date:||June 2012|
|Estimated Study Completion Date:||September 2012|
|Estimated Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
Experimental: active tDCS in DLPFC
Transcranial Direct-Current Stimulation. Patients with ADHD that receive electro-stimulation 20 sessions with 2 mAmp 1 session per day alternative days
Device: Transcranial Direct-Current Stimulation
tDCS applied to left dorsolateral prefrontal scalp area through a saline-soaked pair of surface sponge electrodes (35 cm2). The anode electrode was placed over F3 (based on the 10-20 International EEG System) of each subject. The cathode was placed over the contralateral mastoid area. A constant current of 1.1 mA was applied for 25 min/day (administered for 12 alternated days).
Other Name: Chattanooga Iontophresis
No Intervention: controls
Healthy people that not receive tDCS
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|Contact: Moises Aguilar Domingoemail@example.com|
|Murcia Psychology School||Recruiting|
|Murcia, Spain, 30100|
|Contact: Moises Aguilar 34634541729 firstname.lastname@example.org|
|Principal Investigator: Moises Aguilar Domingo|
|Study Chair:||Moises Aguilar Domingo||Brainmech Foundation|