What is an Important Change in the Short Physical Performance Battery (SPPB)?
The purpose of this study is to determine the important change in the Short Physical Performance Battery (SPPB) when used in patients with lung disease. The SPPB is a simple physical test that measures balance and the functioning of the legs. It has been widely used in healthy elderly populations and predicts hospital admission and the onset of disability. The SPPB has not previously been used in patients with lung disease, and it is not clear what change in this test is considered meaningful and worthwhile by patients or doctors (the minimal clinically important difference: MID). Knowing what the MID for the SPPB will allow researchers and doctors to evaluate the effectiveness of current and new treatments, and to detect improvement or deterioration in the condition of patients.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Determining the Minimal Important Difference of the Short Physical Performance Battery and 4m Gait Speed in Chronic Respiratory Disease Patients.|
- Change from baseline of Short Physical Performance Battery [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
- Change from baseline of MRC Dyspnoea Scale [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
- Change from baseline of St George's Respiratory Questionaire [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
- Anchor question (5-point Likert scale) [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Blood taken and stored as whole blood, serum, and plasma.
|Study Start Date:||March 2012|
|Estimated Study Completion Date:||December 2013|
|Estimated Primary Completion Date:||September 2013 (Final data collection date for primary outcome measure)|
Chronic Respiratory Disease
Any patient with a chronic respiratory disease referred for pulmonary rehabilitation
Other: Pulmonary rehabilitation
An eight week out-patient based programme consisting of twice weekly supervised exercise and educational sessions
Please refer to this study by its ClinicalTrials.gov identifier: NCT01649193
|Harefield, Middlesex, United Kingdom, UB9 6JH|
|Contact: William DC Man, MRCP, PhD 01895 823 737 ext 5851 firstname.lastname@example.org|
|Contact: Samantha SC Kon, BSc, MRCP 01895 823 737 ext 5021 email@example.com|
|Principal Investigator: William DC Man, MRCP, PhD|
|Principal Investigator:||William DC Man, MRCP, PhD||Repiratory Biomedical Reserach Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College London|