Studying Biomarkers in Samples From Younger Patients With Kidney Cancer
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This laboratory study is looking into biomarkers in samples from younger patients with kidney cancer.
Genetic: gene expression analysis
Genetic: protein expression analysis
Other: laboratory biomarker analysis
|Official Title:||Focal Adhesion Kinase Expression in Pediatric Renal Tumors|
- FAK expression in pediatric renal tumors [ Designated as safety issue: No ]
|Study Start Date:||August 2012|
|Estimated Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
- To determine whether focal adhesion kinase (FAK) is expressed and if FAK is phosphorylated in pediatric renal tumors.
OUTLINE: Archived tumor tissue samples are analyzed for FAK expression by immunohistochemistry (IHC). IHC staining is compared in normal renal tissue, Wilms tumor (routine and anaplastic), malignant rhabdoid tumor of the kidney, clear cell sarcoma of the kidney, and mesoblastic nephroma.
PROJECTED ACCRUAL: A total of 40 patient samples will be accrued of the following diagnoses: 10 anaplastic Wilms tumor, 10 malignant rhabdoid tumor of the kidney, 10 clear cell sarcoma of the kidney, and 10 mesoblastic nephroma.
|Principal Investigator:||Elizabeth A. Beierle, MD||Children's Hospital of Alabama at University of Alabama at Birmingham|