Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty
Recruitment status was Recruiting
Patients with knee arthroplasty usually performed under spinal anesthesia with a single-shot femoral nerve block and periarticular block, so we would like to know the plasma concentration of bupivacaine in these patients.
Serum Bupivacaine Level
Total Knee Arthroplasty
|Study Design:||Endpoint Classification: Pharmacokinetics/Dynamics Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Plasma Concentrations of Bupivacaine After Spinal Anesthesia With Single Shot Femoral Nerve Block and Peri-articular Injection in Total Knee Arthroplasty|
- plasma concentration of bupivacaine after spinal anesthesia with single-shot femoral nerve block and periarticular block [ Time Frame: 2 hours ] [ Designated as safety issue: Yes ]
- bupivacaine toxicity [ Time Frame: 24 hr ] [ Designated as safety issue: Yes ]
|Study Start Date:||July 2012|
|Estimated Study Completion Date:||August 2013|
|Estimated Primary Completion Date:||July 2013 (Final data collection date for primary outcome measure)|
20 ml of 0.5% bupivacaine for single-shot femoral nerve block will be done at the beginning then another 20 ml of 0.5% bupivacaine for periarticular block will be performed at the end of operation.
Blood sample will be drawn at 60 min after femoral nerve block and before periarticular block, 15, 30, 45, 60 min after periarticular block.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01636869
|Contact: Saowaphak Lapmahapaisan, M.D.||email@example.com|
|Faculty of Medicine, Siriraj Hospital, Mahidol University||Recruiting|
|Bangkok, Thailand, 10700|
|Contact: Saowaphak Lapmahapaisan, M.D. 662-419-7995 firstname.lastname@example.org|
|Principal Investigator: Saowaphak Lapmahapaisan, M.D.|