The Effect of Attention Bias Modification Training on Reducing Depressive Symptoms

This study is enrolling participants by invitation only.
Sponsor:
Information provided by (Responsible Party):
Wenhui Yang, Hunan Normal University
ClinicalTrials.gov Identifier:
NCT01628016
First received: June 9, 2012
Last updated: June 25, 2012
Last verified: June 2012
  Purpose

The purpose of this study is to test whether attention bias modification training is an effective neurobehavioral therapy to improve depressive symptoms.That is whether attention bias modification training is superior to placebo in reducing depressive symptoms over 1 year after training.


Condition Intervention
Depressive Symptoms
Behavioral: a word dot-probe task for training procedure

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized, Double-blind, Placebo-Controlled Evaluation of the Efficacy of Attentional Bias Modification Training in the Treatment of Depressive Symptoms

Resource links provided by NLM:


Further study details as provided by Hunan Normal University:

Primary Outcome Measures:
  • Change in Beck Depression Inventory-II [ Time Frame: Changes from the baseline in Beck Depression Inventory-II at pre-training to 0, 2 weeks, 4 weeks, 8 weeks, 3 months , 6 months, 12 months post-training ] [ Designated as safety issue: No ]
    The assessment points were pretraining(baseline), posttraining and follow-up at 2-week, 4-week,8-week,3-month, 6-month and 12-month after training completion.


Secondary Outcome Measures:
  • Changes in attentional bias score at dot-probe task, State-Trait Anxiety Inventory-Trait(STAI-T) and Rumination Response Style(RRS) [ Time Frame: Changes from pre-training to post-training in attentional bias scores, and from the baseline in STAI-T and RRS at pre-training to 0, 2weeks, 4weeks, 8weeks, 3months , 6months and 12 months post-training ] [ Designated as safety issue: No ]

Estimated Enrollment: 99
Study Start Date: September 2011
Estimated Study Completion Date: October 2012
Estimated Primary Completion Date: October 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Attentional bias modification training
Participants complete 8 sessions of attention bias modification training (ABMT) during a two-week period. ABMT is a modified dot probe task, in which a probe always appears in the location of neutral stimulus after the two stimuli (i.e. one is the depressive cue and the other is neutral) were simultaneously presented. In the ABMT,the probability that a probe appears in the location of neutral is 90%, and correspondingly,in the location of depressive stimuli is 10%. Each session consists of 218 trials, and the time to complete a training session is approximately 10 minutes.
Behavioral: a word dot-probe task for training procedure
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition, only assessment for blank control condition.
Placebo Comparator: Placebo training
Participants complete 8 sessions of placebo training(PT) during a two-week period. Placebo training is a classic dot probe task, in which a probe appears after either of the locations that the two stimuli (i.e. one is the depressive cue and the other is neutral) were presented, with the same frequencies. In the PT condition, each session also consists of 218 trials, and the time to complete a PT session is approximately 10 minutes as well.
Behavioral: a word dot-probe task for training procedure
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition, only assessment for blank control condition.
No Intervention: blank control
Participants only complete assessment at each point time.
Behavioral: a word dot-probe task for training procedure
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition, only assessment for blank control condition.

Detailed Description:

Attentional bias has been theorized to play a critical role in the onset and maintenance of depression. Attentional bias modification training (ABMT), an experimental paradigm that uses training to induce adaptive attentional bias, was developed to test the causal model and this has therapeutic implications in depression.To test the effect of ABMT on treatment of depressive symptoms, a randomized, double-blind, placebo and blank controlled trial is conducted in college students who are experiencing mild-to-severe symptoms of depression.

  Eligibility

Ages Eligible for Study:   16 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • A score of 14 or higher on the Beck Depression Inventory-II
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01628016

Locations
China, Hunan
Department of Psychology, Hunan Normal University
Changsha, Hunan, China, 400081
Sponsors and Collaborators
Hunan Normal University
Investigators
Principal Investigator: Wenhui Yang, Ph.D Department of Psychology, Hunan Normal University
  More Information

No publications provided

Responsible Party: Wenhui Yang, Department of Psychology, Hunan Normal University
ClinicalTrials.gov Identifier: NCT01628016     History of Changes
Other Study ID Numbers: XJK011AXL002
Study First Received: June 9, 2012
Last Updated: June 25, 2012
Health Authority: China: Ministry of Science and Technology

Keywords provided by Hunan Normal University:
depression
attention
training
modification

Additional relevant MeSH terms:
Depression
Behavioral Symptoms

ClinicalTrials.gov processed this record on July 23, 2014