Human Adaptation to High Altitude
This study is currently recruiting participants.
Verified June 2012 by Zurich Center for Integrative Human Physiology
Sponsor:
Zurich Center for Integrative Human Physiology
Information provided by (Responsible Party):
Zurich Center for Integrative Human Physiology
ClinicalTrials.gov Identifier:
NCT01627652
First received: May 4, 2012
Last updated: June 21, 2012
Last verified: June 2012
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Purpose
This scientific study aims at studying human adaptations to high altitude and the studies will be conducted at the University of Zürich and during a 4 week high altitude "expedition" to the Jungfraujoch research station at 3450 m altitude. The proposal is made up of several independent biological research projects to be conducted in the same healthy volunteers participating in the study. Thus, the subjects will be studied at sea level, and then during 4 weeks of acclimatization to high altitude, and for some experimental purposes all subjects will also be studied one and two weeks after return to sea level.
| Condition | Intervention |
|---|---|
|
Hypoxia |
Other: altitude |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Basic Science |
| Official Title: | Human Adaptation to High Altitude |
Further study details as provided by Zurich Center for Integrative Human Physiology:
Primary Outcome Measures:
- Human adaptation to high altitude [ Time Frame: May-June, 2012 ] [ Designated as safety issue: No ]The primary outcome measure are changes in red cell blood mass, cardiac output, middle cerebral blood flow, muscle sympathetic activity and mitochondrial function.
| Estimated Enrollment: | 8 |
| Study Start Date: | April 2012 |
| Estimated Study Completion Date: | September 2012 |
| Estimated Primary Completion Date: | July 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: altitude
subjects will be studies at sea level and at high altitude
|
Other: altitude
the subjects will live one month at 3450 m altitude in the Jungfraujoch Research Station
Other Name: Jungfraujoch Research Station
|
Show Detailed Description Eligibility| Ages Eligible for Study: | 18 Years to 35 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- 18 to 35 yrs of age
- male
- healthy
Exclusion Criteria:
- smokers
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01627652
Contacts
| Contact: Carsten Lundby, PhD | 0041446355052 | carsten.lundby@access.uzh.ch |
Locations
| Switzerland | |
| University of Zürich and the JUngfraujoch Research Station | Recruiting |
| Zürich and Jungfraujoch (mountain), Switzerland, 8057 | |
| Contact: Carsten Lundby, PhD 0041446355052 carsten.lundby@access.uzh.ch | |
Sponsors and Collaborators
Zurich Center for Integrative Human Physiology
More Information
Additional Information:
No publications provided
| Responsible Party: | Zurich Center for Integrative Human Physiology |
| ClinicalTrials.gov Identifier: | NCT01627652 History of Changes |
| Other Study ID Numbers: | EK 2011-N-51 |
| Study First Received: | May 4, 2012 |
| Last Updated: | June 21, 2012 |
| Health Authority: | Switzerland: Ethikkommission |
Keywords provided by Zurich Center for Integrative Human Physiology:
|
hypoxia |
Additional relevant MeSH terms:
|
Anoxia Signs and Symptoms, Respiratory Signs and Symptoms |
ClinicalTrials.gov processed this record on June 18, 2013