Human Adaptation to High Altitude

This study is currently recruiting participants.
Verified June 2012 by Zurich Center for Integrative Human Physiology
Sponsor:
Information provided by (Responsible Party):
Zurich Center for Integrative Human Physiology
ClinicalTrials.gov Identifier:
NCT01627652
First received: May 4, 2012
Last updated: June 21, 2012
Last verified: June 2012
  Purpose

This scientific study aims at studying human adaptations to high altitude and the studies will be conducted at the University of Zürich and during a 4 week high altitude "expedition" to the Jungfraujoch research station at 3450 m altitude. The proposal is made up of several independent biological research projects to be conducted in the same healthy volunteers participating in the study. Thus, the subjects will be studied at sea level, and then during 4 weeks of acclimatization to high altitude, and for some experimental purposes all subjects will also be studied one and two weeks after return to sea level.


Condition Intervention
Hypoxia
Other: altitude

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Human Adaptation to High Altitude

Further study details as provided by Zurich Center for Integrative Human Physiology:

Primary Outcome Measures:
  • Human adaptation to high altitude [ Time Frame: May-June, 2012 ] [ Designated as safety issue: No ]
    The primary outcome measure are changes in red cell blood mass, cardiac output, middle cerebral blood flow, muscle sympathetic activity and mitochondrial function.


Estimated Enrollment: 8
Study Start Date: April 2012
Estimated Study Completion Date: September 2012
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: altitude
subjects will be studies at sea level and at high altitude
Other: altitude
the subjects will live one month at 3450 m altitude in the Jungfraujoch Research Station
Other Name: Jungfraujoch Research Station

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18 to 35 yrs of age
  • male
  • healthy

Exclusion Criteria:

  • smokers
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01627652

Contacts
Contact: Carsten Lundby, PhD 0041446355052 carsten.lundby@access.uzh.ch

Locations
Switzerland
University of Zürich and the JUngfraujoch Research Station Recruiting
Zürich and Jungfraujoch (mountain), Switzerland, 8057
Contact: Carsten Lundby, PhD    0041446355052    carsten.lundby@access.uzh.ch   
Sponsors and Collaborators
Zurich Center for Integrative Human Physiology
  More Information

No publications provided

Responsible Party: Zurich Center for Integrative Human Physiology
ClinicalTrials.gov Identifier: NCT01627652     History of Changes
Other Study ID Numbers: EK 2011-N-51
Study First Received: May 4, 2012
Last Updated: June 21, 2012
Health Authority: Switzerland: Ethikkommission

Keywords provided by Zurich Center for Integrative Human Physiology:
hypoxia

Additional relevant MeSH terms:
Anoxia
Signs and Symptoms, Respiratory
Signs and Symptoms

ClinicalTrials.gov processed this record on April 15, 2014