Use Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty
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Purpose
The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.
| Condition | Intervention |
|---|---|
|
Periprosthetic Bone Loss in Total Knee Replacement |
Radiation: dual energy x-ray absorptiometry |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Use Dual-energy X-ray Absorptiometry and Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty |
- change in bone mineral density [ Time Frame: before the surgery and after the sugery (6month ,12month) ] [ Designated as safety issue: No ]Use dual energy x-ray absorptiometry to detect to BMD at the distal femur
Biospecimen Retention: Samples With DNA
A 2X1X0.5cm bone fragment harvested during the chamfer cut of total knee arthroplasty
| Estimated Enrollment: | 50 |
| Study Start Date: | July 2012 |
| Estimated Study Completion Date: | July 2013 |
| Estimated Primary Completion Date: | July 2013 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
severe knee OA who are indicated for total knee arthroplasty
the woman who are indicated for TKR and are post menopausal will be recruited in this study. We will excluded the patients who had immune disease ,previous fracture of femur and end stage of renal disease
|
Radiation: dual energy x-ray absorptiometry
before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months
|
Eligibility| Ages Eligible for Study: | 50 Years to 70 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
the patients who are indicated for total knee arthroplasty and are post menopausal women. The patients who had history of immune disease , fracture of the femur and end stage of renal disease will be excluded
Inclusion Criteria:
- severe knee osteoarthritis
- post menopausal women
Exclusion Criteria:
- immune disease
- end stage of renal disease who receive dialysis
- history of fracture at ipsilateral distal femur
Contacts and Locations| Contact: Ching Chuan Jiang, professor | 23123456 ext 65273 | ccj@ntu.edu.tw |
| Contact: Wei cheng Huang, resident | osteocheng@gmail.com |
| Taiwan | |
| National taiwan university hospital | Not yet recruiting |
| Taipei, Taiwan, 100 | |
| Contact: Ching Chuan Jiang, professoir 886223123456 ext 65273 ccj@ntu.edu.tw | |
| Principal Investigator: | ching chuan Jiang, professor | National Taiwan University Hospital |
More Information
No publications provided
| Responsible Party: | National Taiwan University Hospital, Use dual-energy x-ray absorptiometry and quantative microradiography to predict the periprosthetic bone loss in distal femur after total knee arthroplasty |
| ClinicalTrials.gov Identifier: | NCT01618149 History of Changes |
| Other Study ID Numbers: | 201204035RIB |
| Study First Received: | June 11, 2012 |
| Last Updated: | June 12, 2012 |
| Health Authority: | Taiwan: Department of Health United States: Institutional Review Board |
Keywords provided by National Taiwan University Hospital:
|
osteoarthritis periprosthetic bone loss dual energy x-ray absorptiometry |
ClinicalTrials.gov processed this record on June 18, 2013