Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen (supplement)
There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements like zinc. Zinc in human seminal plasma was divided into three types of ligands which are high (HMW), intermediate (IMW), and low molecular weight ligands (LMW). The present study was conducted to study the effect of Zn supplementation on the quantitative and qualitative characteristics of semen along with Zinc Binding Protein levels in semen of patients with asthenozoospmia.
|Study Design:||Observational Model: Case Control
Time Perspective: Retrospective
|Official Title:||Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen|
- high molecular weight zinc binding protein [ Time Frame: at the end of three months ] [ Designated as safety issue: Yes ]elevated levels of high molecular weight zinc binding protein to normal value
- qualitative semen parameters [ Time Frame: at the end of three months ] [ Designated as safety issue: Yes ]Volume of semen, progressive sperm motility percentage and total normal sperm count increased after zinc sulfate supplementation.
|Study Start Date:||July 2011|
|Study Completion Date:||April 2012|
|Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
Single group: all participants receive same intervention throughout study (Non-randomised)
Dietary Supplement: zinc sulfate
every participant took two capsules of zinc sulfate per day for three months (each one 220mg)
Other Name: infertility
Elevation of ROS levels lead to an increase the oxidation of HMW-Zn binding proteins in seminal plasma of asthenozoospermic subjects. Zinc supplementation restores HMW-Zn% in seminal plasma of asthenozoospermic subjects to normal value. LMW-Zn% is elevated in seminal plasma of asthenozoospermic patients. It may be because increment the levels of semenogelin in seminal plasma of asthenozoospermic subjects. Zinc supplementation elevates LMW-Zn% in seminal plasma of asthenozoospermic subjects to more than normal value, this may be because of its enhancement of the synthesis of metallothioneins (Low molecular weight zinc binding protein).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01612403
|Babylon university/ college of science|
|Hilla, Iraq, IQ|
|Hilla, Iraq, IQ|
|Principal Investigator:||mahmoud H. hadwan, Dr.||babylon university / Iraq|