Effects of Glucose-fructose Drinks During Training on Lactate Transport (LactEx)

This study has been completed.
Sponsor:
Collaborator:
Centre Hospitalier Universitaire Vaudois
Information provided by (Responsible Party):
Luc Tappy, MD, University of Lausanne
ClinicalTrials.gov Identifier:
NCT01610986
First received: May 23, 2012
Last updated: June 3, 2014
Last verified: June 2014
  Purpose

The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.


Condition Intervention
Normal Physiology on Healthy Subjects
Dietary Supplement: Glucose-fructose
Dietary Supplement: Water

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effects of Glucose-fructose Drinks During Training on Lactate Transport and Oxidation and on Endurance Performance

Resource links provided by NLM:


Further study details as provided by University of Lausanne:

Primary Outcome Measures:
  • Change in lactate transport [ Time Frame: At baseline (before training) and after the 3-week training protocol ] [ Designated as safety issue: No ]
    Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)


Secondary Outcome Measures:
  • Change in muscle monocarboxylate transporters (MCTs) expression and protein content [ Time Frame: At baseline (before training) and after the 3-week training protocol ] [ Designated as safety issue: No ]
    MCTs expression (mRNA) and protein content after muscle biopsy


Enrollment: 17
Study Start Date: May 2012
Study Completion Date: March 2014
Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Glucose-fructose
Participants will take glucose-fructose drinks during training sessions
Dietary Supplement: Glucose-fructose
0.8 g/h glucose and 0.5 g/h fructose during training
Experimental: Water
Participants will take only water during training sessions
Dietary Supplement: Water
Only water intake during training

Detailed Description:

The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

  Eligibility

Ages Eligible for Study:   18 Years to 30 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy
  • age between 18 and 30 years
  • sedentary
  • BMI between 19 and 25
  • blood pressure lower than 140/90 mmHg

Exclusion Criteria:

  • smoking
  • consumption of more than 10g alcohol per day
  • cardiovascular history
  • electrographic abnormalities at rest
  • consumption of more than one can of soda per day or more than 60g sugars per day
  • any current drug treatment
  • consumption of drugs or illicit substances
  • diabetes mellitus
  • vegetarian
  • food intolerance
  • blood donation or participation to another study <3 months before study inclusion
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01610986

Locations
Switzerland
University of Lausanne
Lausanne, Vaud, Switzerland, 1005
Sponsors and Collaborators
University of Lausanne
Centre Hospitalier Universitaire Vaudois
Investigators
Principal Investigator: Luc Tappy, Pr University of Lausanne
  More Information

Publications:
Responsible Party: Luc Tappy, MD, Professor of Physiology, University of Lausanne
ClinicalTrials.gov Identifier: NCT01610986     History of Changes
Other Study ID Numbers: 251/11
Study First Received: May 23, 2012
Last Updated: June 3, 2014
Health Authority: Switzerland: Ethikkommission

Keywords provided by University of Lausanne:
Fructose
Exercise
Lactic acid
Monocarboxylic Acid Transporters

ClinicalTrials.gov processed this record on October 01, 2014