Prospective Randomized Study of Glucocorticoids in the Impact of the Liver Function and the Prognosis After Hepatectomy of HCC

This study has suspended participant recruitment.
Sponsor:
Information provided by (Responsible Party):
jian zhai, Eastern Hepatobiliary Surgery Hospital
ClinicalTrials.gov Identifier:
NCT01608945
First received: May 29, 2012
Last updated: May 30, 2012
Last verified: May 2012
  Purpose

The major drawback of hepatic pedicle clamping is ischaemia-reperfusion injury with impairment of liver function. Perioperative steroid administration has been advocated to reduce liver damage. The aim of this prospective, randomized study was to determine whether steroid administration can reduce liver injury and impact the prognosis


Condition Intervention
Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver
Drug: Hydrocortisone sodium succinate

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Eastern Hepatobiliary Surgery Hospital:

Primary Outcome Measures:
  • liver function [ Time Frame: six months ] [ Designated as safety issue: No ]

Enrollment: 60
Study Start Date: April 2008
Groups/Cohorts Assigned Interventions
steroid,liver function I/R Drug: Hydrocortisone sodium succinate
100mg/day

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

60

Criteria

Inclusion Criteria:

  • 18-70 years old
  • diametre of the mass>3cm.
  • hcc
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: jian zhai, hepatic department, Eastern Hepatobiliary Surgery Hospital
ClinicalTrials.gov Identifier: NCT01608945     History of Changes
Other Study ID Numbers: EHBH112
Study First Received: May 29, 2012
Last Updated: May 30, 2012
Health Authority: China: Ethics Committee

Keywords provided by Eastern Hepatobiliary Surgery Hospital:
steroid
liver function
prognosis

Additional relevant MeSH terms:
Wounds and Injuries
Glucocorticoids
Hydrocortisone acetate
Hydrocortisone 17-butyrate 21-propionate
Cortisol succinate
Hydrocortisone
Hydrocortisone-17-butyrate
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions
Anti-Inflammatory Agents
Therapeutic Uses
Dermatologic Agents

ClinicalTrials.gov processed this record on August 20, 2014