Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control
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Purpose
Dietary pulses (beans, peas, chickpeas, and lentils), more commonly known as "legumes", are generally recognized as healthy components of the diet. Canada's Food Guide encourages consumptions of meat alternatives, such as beans "more often"; and the dietary guidelines for Americans both recommend consumption of 3 cups of legumes per week. However, there remains insufficient information on the usefulness of these foods in protecting heart health. To improve evidence-based guidance for dietary pulse recommendations, the investigators propose to conduct a systematic review of the effect of dietary pulse consumption on after-meal blood sugar levels, appetite, and food intake regulation to help explain their mechanism for improving longterm blood sugar and body weight control. The systematic review process allows the combining of the results from many small studies in order to arrive at a pooled estimate, similar to a weighted average, of the true effect. The investigators will be able to explore whether eating pulses has different effects between men and women, in different age groups and background disease states, and whether or not the effect of pulses depends on the dose and background diet. The findings of this proposed knowledge synthesis will help improve the health of Canadians through informing recommendations for the general public, as well as those at risk of heart disease and diabetes.
| Condition | Intervention |
|---|---|
|
Diabetes Prediabetes Dysglycemia Overweight Obesity Metabolic Syndrome Cardiovascular Disease |
Other: Dietary pulses |
| Study Type: | Observational |
| Study Design: | Time Perspective: Prospective |
| Official Title: | Effect of Dietary Pulses on Acute Postprandial Glycemia and Food Intake Regulation: A Systematic Review and Meta-analyses |
- Effect of pulse consumption on post-prandial glycemia in acute, single bolus controlled feeding trials. [ Time Frame: Up to 1.5-years ] [ Designated as safety issue: No ]Area under the curve [AUC], glycemic index (GI)
- Effect of pulse consumption on satiety in acute, single bolus controlled feeding trials. [ Time Frame: Up to 1.5-years ] [ Designated as safety issue: No ]Subjective appetite scores, 2nd meal intake
| Estimated Enrollment: | 1 |
| Study Start Date: | October 2011 |
| Estimated Study Completion Date: | March 2013 |
| Estimated Primary Completion Date: | October 2012 (Final data collection date for primary outcome measure) |
-
Other: Dietary pulses
Show Detailed Description
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Varied
Inclusion Criteria:
- dietary trials in humans
- acute, single bolus feeding
- control matched for available carbohydrate
- viable endpoint data
Exclusion Criteria:
- non-human studies
- chronic feeding
- lack of a suitable control (not matched for available carbohydrate)
- no viable endpoint data
Contacts and Locations| Canada, Ontario | |
| The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Micheal's Hospital | |
| Toronto, Ontario, Canada, M5C 2T2 | |
| Study Director: | John L Sievenpiper, MD, PhD | Department of Pathology and Molecular Medicine, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital |
| Study Director: | Russell J de Souza, ScD, RD | Department of Epidemiology and Biostatistics, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital |
| Principal Investigator: | David JA Jenkins, MD, PhD, DSc | Department of Nutritional Sciences and Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital |
| Study Director: | Cyril WC Kendall, PhD | Department of Nutritional Sciences, University of Toronto and College of Pharamcy and Nutrition, University of Saskatchewan |
More Information
Publications:
| Responsible Party: | John Sievenpiper, Adjunct Research Fellow, University of Toronto |
| ClinicalTrials.gov Identifier: | NCT01605422 History of Changes |
| Other Study ID Numbers: | PC 2011 KRS |
| Study First Received: | May 18, 2012 |
| Last Updated: | August 24, 2012 |
| Health Authority: | Canada: Ethics Review Committee |
Keywords provided by University of Toronto:
|
Systematic review and meta-analysis Evidence-based medicine (EBM) Evidence-based nutrition (EBN) Clinical practice guidelines Clinical trials Dietary pulses legumes Beans, peas, chickpeas, lentils |
glycemic index postprandial glycemia insulin resistance body weight appetite food intake regulation satiety satiation |
Additional relevant MeSH terms:
|
Cardiovascular Diseases Obesity Glucose Intolerance Prediabetic State Overweight Metabolic Syndrome X Overnutrition Nutrition Disorders Body Weight |
Signs and Symptoms Hyperglycemia Glucose Metabolism Disorders Metabolic Diseases Diabetes Mellitus Endocrine System Diseases Insulin Resistance Hyperinsulinism |
ClinicalTrials.gov processed this record on May 21, 2013