Acute Effects of Exercise in Women With Fibromyalgia (FM)
The investigators previous studies of aerobic exercise in women with fibromyalgia (FM) have shown that exercise improves body functions and/or symptom severity in most patients, but not in all. About a third of patients with FM have been shown to have low levels of IGF-1. The purpose of this project is to study individual and biological factors that interact with outcomes of short-term (acute) exercise in FM.
Method. A controlled prospective exercise study. Thirty women with FM and 30 healthy age-matched women, aged 20-50 years, will be recruited to the study. Two 15-minute ergometer bicycle exercise tests will be conducted in feasting patients, separated by one month. The first exercise test is at a low and the second at a high intensity. Measurements comprise blood test, pain rating and pain threshold, conducted before and after the test. The levels of IGF-1, IL-6 and IL-8 will be measured, and the changes in them will be related to health status and pain.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Acute Effects of Exercise in Women With FM|
- IGF1 level [ Time Frame: 15 min ] [ Designated as safety issue: No ]Ergometer cycle test of 15 minutes at low respective high intensity. Blood test is done before and after exercise. Change in quantity of IGF1 is measured.
- Pain rating [ Time Frame: 15 minutes ] [ Designated as safety issue: No ]Pain is rated by the test person before and after the ergometer cycle test.
- Pain threshold [ Time Frame: 15 minutes ] [ Designated as safety issue: No ]Pain threshold is measured before and after the ergometer test.
- Interleukin 6 and 8 [ Time Frame: 15 minutes ] [ Designated as safety issue: No ]Blood test is done before and after the ergometer bicycle test. Quantity of interleukin 6 and 8 is measured.
Biospecimen Retention: Samples Without DNA
|Study Start Date:||May 2012|
|Estimated Study Completion Date:||October 2014|
|Estimated Primary Completion Date:||September 2014 (Final data collection date for primary outcome measure)|
Women with fibromyalgia, aged 20-50 years
Women without severe disease, aged 20-50 years
Please refer to this study by its ClinicalTrials.gov identifier: NCT01592916
|Contact: Kaisa Mannerkorpi, Assoc firstname.lastname@example.org|
|Sahlgrenska University Hospital, Dept of Physical Therapy||Recruiting|
|Göteborg, Sweden, 41345|
|Contact: Kaisa E Mannerkorpi, Ass prof 0046-31-3421195 email@example.com|
|Principal Investigator:||Kaisa Mannerkorpi, Assoc prof||Göteborg University|