F18-FLT PET/CT as a Tool for Assessment of Myeloablative Treatment in Patients With Acute Myeloid Leucemia(AML) (AML F18-FLT)
PET/CT is reliable tool in evaluation of treatment response in number cancers. F18-FLT is a precursor of DNA with high uptake in the bone marrow as a part of normal biodistribution. Highly increased uptake of this radiopharmaceutical was shown in a number of hematologic disease either in bone marrow or extramedullary.
F18-FLT PET/CT can provide a tool for whole body assessment of activity in bone marrow as well as early estimation of treatment efficacy or lack of it. In addition, this noninvasive study can replace bone marrow biopsy and predict response vs. non response to therapy.
Acute Myeloid Leucemia
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||F18-FLT PET/CT as a Tool for Assessment of Myeloablative Treatment in Patients With AML|
- Measure of extent and intensity ( by standardized uptake value - SUV) of disease in bone marrow demonstrated on PET/CT images before and after treatment.
- prediction of treatment response by dynamics of FLT uptake(by SUV)in comparison to bone marrow biopsy
|Study Start Date:||October 2012|
|Estimated Primary Completion Date:||October 2013 (Final data collection date for primary outcome measure)|
patients with AML prior and after treatment
|Contact: Marina Orevi, MDemail@example.com|
|Hadassah Hebrew University Medical Center||Not yet recruiting|
|Principal Investigator: Marina Orevi, MD|