Identification the Expression of Sox2 in Colorectal Cancer Tissues
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Purpose
Sox2 has been studied in several types of human solid tumors. The investigators found that Sox2 had higher expression level in colorectal cancer and metastatic tissues than normal tissues. So the investigators assumed that whether Sox2 plays an important role in the progression and migration of colon cancer.
| Condition |
|---|
|
Colorectal Cancer |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Retrospective |
| Official Title: | The Role of Sox2 in Tumor Genesis and Migration in Colorectal Cancer |
| Enrollment: | 136 |
| Study Start Date: | January 2005 |
| Study Completion Date: | March 2012 |
| Primary Completion Date: | December 2006 (Final data collection date for primary outcome measure) |
In our study, we examined Sox2 expression in archived human colon cancer tissues and found that its Sox2 expression correlates with reduced patient survival, increased tumor grade and metastasis probability.
Eligibility| Ages Eligible for Study: | 24 Years to 79 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
All rchived 136 tissues were obtained and pathologically confirmed from patients who underwent surgical resections between 2005 and 2006 at the Cancer Center of Sun Yat-sen University (Guangzhou, Guangdong, P. R. China)). The patients from whom the samples were derived underwent curative resection between 2005 and 2006. Tumor differentiation was characterized according to WHO classification, while the surgical pathologic stage was analyzed according to the TNM classification system of the International Union against Cancer. All samples were anonymously coded in accordance with local ethical guidelines.
Inclusion Criteria:
- Clinical diagnosis of colorectal cancer
Exclusion Criteria:
- Clinical diagnosis characteristics not exactly described in the patients information
Contacts and Locations More Information
Additional Information:
No publications provided
| Responsible Party: | Lixiao Xu, Laboratory of Cancer and Stem Cell Biology, Sun Yat-sen University |
| ClinicalTrials.gov Identifier: | NCT01589900 History of Changes |
| Other Study ID Numbers: | SYSU |
| Study First Received: | April 30, 2012 |
| Last Updated: | May 2, 2012 |
| Health Authority: | China: Ministry of Science and Technology |
Keywords provided by Sun Yat-sen University:
|
colorectal cancer invasion metastasis IHC |
Additional relevant MeSH terms:
|
Colorectal Neoplasms Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Neoplasms by Site Neoplasms |
Digestive System Diseases Gastrointestinal Diseases Colonic Diseases Intestinal Diseases Rectal Diseases |
ClinicalTrials.gov processed this record on June 18, 2013