Identification the Expression of Sox2 in Colorectal Cancer Tissues
This study has been completed.
Information provided by (Responsible Party):
Lixiao Xu, Sun Yat-sen University
First received: April 30, 2012
Last updated: May 2, 2012
Last verified: May 2012
Sox2 has been studied in several types of human solid tumors. The investigators found that Sox2 had higher expression level in colorectal cancer and metastatic tissues than normal tissues. So the investigators assumed that whether Sox2 plays an important role in the progression and migration of colon cancer.
||Observational Model: Cohort
Time Perspective: Retrospective
||The Role of Sox2 in Tumor Genesis and Migration in Colorectal Cancer
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||December 2006 (Final data collection date for primary outcome measure)
In our study, we examined Sox2 expression in archived human colon cancer tissues and found that its Sox2 expression correlates with reduced patient survival, increased tumor grade and metastasis probability.
|Ages Eligible for Study:
||24 Years to 79 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
All rchived 136 tissues were obtained and pathologically confirmed from patients who underwent surgical resections between 2005 and 2006 at the Cancer Center of Sun Yat-sen University (Guangzhou, Guangdong, P. R. China)). The patients from whom the samples were derived underwent curative resection between 2005 and 2006. Tumor differentiation was characterized according to WHO classification, while the surgical pathologic stage was analyzed according to the TNM classification system of the International Union against Cancer. All samples were anonymously coded in accordance with local ethical guidelines.
- Clinical diagnosis of colorectal cancer
- Clinical diagnosis characteristics not exactly described in the patients information
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01589900
Sun Yat-sen University
||Yan Zhang, M.D.Ph.D
||Laboratory of Cancer and Stem Cell Biology School of Life Sciences Sun Yat-sen University
No publications provided
||Lixiao Xu, Laboratory of Cancer and Stem Cell Biology, Sun Yat-sen University
History of Changes
|Other Study ID Numbers:
|Study First Received:
||April 30, 2012
||May 2, 2012
||China: Ministry of Science and Technology
Keywords provided by Sun Yat-sen University:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on August 19, 2014
Digestive System Neoplasms
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