Study of the Effect of Diabetes on the Incidence and the Extent of Coronary Artery Disease
Recruitment status was Recruiting
In the present study the investigators will measure the extent of coronary artery disease via coronary angiography and the correlating risk factors.
Patients Undergoing Coronary Angiography
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||The Role of Newer and Traditional Risk Factors in the Development, Extent and Manifestation of Coronary Artery Disease|
- The incidence and extent of coronary artery disease between diabetics and non-diabetic patients. [ Time Frame: Up to four years on average. ] [ Designated as safety issue: No ]We will investigate the incidence, extent and clinical manifestation of coronary artery disease in diabetics and non-diabetics undergoing coronary angiography for clinical reasons.
- The incidence and extent of coronary artery disease via coronary angiography scores and related biochemical and demographical risk factors. [ Time Frame: Up to 4 years on average. ] [ Designated as safety issue: No ]To associate the incidence, extent and clinical manifestation of coronary artery disease with classic demographic risk factors (such as smoking, alcohol consumption, physical exercise, arterial hypertension, family history of diabetes mellitus or coronary artery disease) and common biochemical risk factors (such as fasting glucose levels, urea, creatinine, HbA1c%, uric acid, total cholesterol, HDL, LDL, triglycerides, VLDL, glomerular filtration rate - GFR).
- The incidence, extent and clinical manifestation of coronary artery disease and the circulating levels of hs-CRP, adipokines and RAGEs. [ Time Frame: Up to 4 years on average. ] [ Designated as safety issue: No ]To associate the incidence, extent and clinical manifestation of coronary artery disease with systemic inflammatory status assessed by hs-CRP levels, circulating adipokines (adiponectin, resistin) and the receptors of advanced glycation end products (sRAGE and esRAGE).
- TCF7L2 gene polymorphims and the incidence and extent of coronary artery disease. [ Time Frame: Within a maximum period of 4 years. ] [ Designated as safety issue: No ]To associate the incidence, extent and clinical manifestation of coronary artery disease with the rs7903146 single nucleotide polymorphism of TCF7L2 gene, that has been strongly associated with diabetes mellitus development.
Biospecimen Retention: Samples With DNA
Includes retaining blood samples for DNA analyses and biomechemical markers.
|Study Start Date:||November 2009|
|Estimated Study Completion Date:||November 2013|
|Estimated Primary Completion Date:||November 2012 (Final data collection date for primary outcome measure)|
All patients undergoing coronary angiography who are diabetics.
No diabetes mellitus
All patients undergoing coronary angiography that are non-diabetics.
Coronary angiography patients
Diabetics and non-diabetics with or without known CV disease who are admitted in the Department of Cardiology in the University Hospital of Ioannina and the Catheterization Laboratory of 1st IKA Hospital in Athens and undergo coronary angiography for clinical purposes will be studied. The study will include subjects who 1) have suspected CAD and undergo a scheduled diagnostic angiogram for clinical reasons, and 2) are hospitalized because of an acute coronary syndrome and thus undergo diagnostic angiography (with or without previous history of CAD).
In the present study the investigators will examine the risk factors determining the development, extent and the manifestation of coronary artery disease. The study will recruit patients undergoing coronary angiography for clinical purposes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01585948
|Contact: Lampros Michalis, Professor||26510 07710 ext email@example.com|
|Contact: Katerina Naka, Lecturer||26510 07710 ext firstname.lastname@example.org|
|Cardiology Department, University Hospital of Ioannina||Recruiting|
|Ioannina, Greece, 45110|
|Sub-Investigator: Aikaterini Marini, MD|
|Principal Investigator:||Katerina Naka, Lecturer||University of Ioannina|