Bananas as an Energy Source During Exercise: a Metabolomics Approach

This study has been completed.
Sponsor:
Collaborator:
Dole Food Company
Information provided by (Responsible Party):
David C. Nieman, Appalachian State University
ClinicalTrials.gov Identifier:
NCT01581190
First received: April 14, 2012
Last updated: April 18, 2012
Last verified: April 2012
  Purpose

This study compared the acute effect of ingesting bananas (BAN) versus a 6% carbohydrate drink (CHO) on 75-km cycling performance and post-exercise inflammation, oxidative stress, and innate immune function using traditional and metabolomics-based profiling.


Condition Intervention
Intense Exercise
Dietary Supplement: Bananas versus 6% carbohydrate beverage

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Comparison of Bananas and Gatorade on Performance and Exercise-induced Inflammation, Oxidative Stress, and Changes in Immune Function in Endurance Athletes

Resource links provided by NLM:


Further study details as provided by Appalachian State University:

Primary Outcome Measures:
  • Performance and fuel substrate utilization as measured through metabolomics [ Time Frame: Up to 6 months ] [ Designated as safety issue: No ]
    Will measure shifts in metabolites following 75-km cycling while ingesting bananas or 6% carbohydrate beverage. The shift in metabolites will be assessed using GC-MS. Time frame from date of randomization until the last samples are collected and analyzed will be up to six months.


Secondary Outcome Measures:
  • Exercise-induced inflammation. [ Time Frame: up to 6 months ] [ Designated as safety issue: No ]
    Cytokine panel (IL-6, IL-8, IL-10, TNF-alpha) before and after cycling 75-km; measured with Meso Scale Discovery in pg/ml. Time frame from randomization until the last samples are collected and analyzed will be up to six months.


Enrollment: 14
Study Start Date: September 2011
Study Completion Date: November 2011
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Bananas versus 6% carbohydrate beverage Dietary Supplement: Bananas versus 6% carbohydrate beverage
Trained cyclists (N=14) completed two 75-km cycling time trials (randomized, crossover) while ingesting BAN or CHO (0.2 g/kg carbohydrate every 15 min).
Other Name: Gatorade

Detailed Description:

Trained cyclists (N=14) completed two 75-km cycling time trials (randomized, crossover) while ingesting BAN or CHO (0.2 g/kg carbohydrate every 15 min). Pre-, post-, and 1-h-post-exercise blood samples were analyzed for glucose, granulocyte (GR) and monocyte (MO) phagocytosis (PHAG) and oxidative burst activity, nine cytokines, F2-isoprostanes, ferric reducing ability of plasma (FRAP), and metabolic profiles using gas chromatography-mass spectrometry.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male
  • Ages 18-45 years
  • Cyclists, road racing experience.
  • Willing to avoid the use of supplements, herbs, medications during the study.

Exclusion Criteria:

  • Female
  • Over the age of 45 years
  • No cycling racing experience
  • Using supplements and medications during the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01581190

Locations
United States, North Carolina
Human Performance Lab, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28081
Sponsors and Collaborators
Appalachian State University
Dole Food Company
Investigators
Principal Investigator: David C Nieman, DrPH Appalachian State University
  More Information

Additional Information:
No publications provided

Responsible Party: David C. Nieman, Professor, Director of the Human Performance Lab, Appalachian State University
ClinicalTrials.gov Identifier: NCT01581190     History of Changes
Other Study ID Numbers: 11-0082
Study First Received: April 14, 2012
Last Updated: April 18, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Appalachian State University:
Bananas
Exercise
Metabolomics
Oxidative stress
Inflammation
Immune function

ClinicalTrials.gov processed this record on September 30, 2014