Sleep Duration Required to Restore Performance During Chronic Sleep Restriction - Full Text View

Purpose

The purpose of this study is to test the hypothesis that sleep and performance depend on length of time awake, length of time asleep, the amount of sleep over several sleep episodes, and circadian phase.

Condition	Intervention
Sleep Sleep Deprivation Insufficient Sleep Syndrome	Behavioral: Sleep:wake 1 Behavioral: Sleep:wake 2

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Subject) Primary Purpose: Basic Science
Official Title:	Sleep Duration Required to Restore Performance During Chronic Sleep Restriction

Further study details as provided by Brigham and Women's Hospital:

Primary Outcome Measures:

Psychomotor Vigilance Task (PVT) performance [ Time Frame: PVT during waking for arms 1 and 2 during the 32-day inpatient portion of the protocol ] [ Designated as safety issue: No ]
PVT metrics are reaction time. It is measured when the participants are awake during the inpatient portion of the protocol.

Estimated Enrollment:	20
Study Start Date:	April 2012
Estimated Primary Completion Date:	June 2016 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: Sleep:wake 2 Sleep and wake durations for arm 2 for inpatient portion of protocol. .There are a variety of sleep and wake durations during the protocol; some of these are longer and some are shorter and some are the same as in arm 1.	Behavioral: Sleep:wake 2 Sleep and Wake durations for arm2
Experimental: Sleep:wake 1 Sleep and wake durations for arm 1 of the inpatient portion of the protocol. There are a variety of sleep and wake durations during the protocol; some of these are longer and some are shorter and some are the same as in arm 2.	Behavioral: Sleep:wake 1 Sleep and Wake durations for arm 1

Detailed Description:

The purpose of this study is to test the hypothesis that sleep and performance depend on length of time awake, length of time asleep, the amount of sleep over several sleep episodes, and circadian phase. Inpatient sleep and performance data will be collected from healthy volunteers.

Eligibility

Ages Eligible for Study:	18 Years to 35 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy

Exclusion Criteria:

Prescription medications

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01581125

Contacts

Contact: Elizabeth B Klerman, MD PhD

617-732-5500 ext 33848

ebklerman@rics.bwh.harvard.edu

Locations

United States, Massachusetts
Brigham and Women's Hospital	Recruiting
Boston, Massachusetts, United States, 02115
Contact: Recruiters 617-732-4311 light@rics.bwh.harvard.edu
Principal Investigator: Elizabeth B Klerman, MD PhD

Sponsors and Collaborators

Brigham and Women's Hospital

Investigators

Principal Investigator:

Elizabeth B Klerman, MD PhD

Brigham and Women's Hospital

More Information

No publications provided

Responsible Party:	Elizabeth B. Klerman, Associate Professor, Associate Physician, Brigham and Women's Hospital
ClinicalTrials.gov Identifier:	NCT01581125 History of Changes
Other Study ID Numbers:	NIH R01 HL114088-01
Study First Received:	March 22, 2012
Last Updated:	March 7, 2013
Health Authority:	United States: Institutional Review Board

Keywords provided by Brigham and Women's Hospital:

Inpatients
Health Normalcy
circadian rhythm

Additional relevant MeSH terms:

Sleep Deprivation
Dyssomnias
Sleep Disorders
Nervous System Diseases

Neurologic Manifestations
Signs and Symptoms
Mental Disorders

ClinicalTrials.gov processed this record on May 21, 2013