Obstructive Sleep Apnea in Pulmonary Embolism
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Purpose
Obstructive sleep apnea (OSA) is a clinical syndrome characterized by repetitive closure of the airway and frequent awakenings during sleep. Repeated episodes of hypoxia, decrease in intrathoracic pressure, increased venous return and venous stasis, damage to vascular wall may ensue. An increased tendency for coagulation has also been reported in OSA. Venous stasis, vascular endothelial activation and hypercoagulability are also known risk factors for thromboembolism. All of these pathophysiologic changes in OSA may predispose patients for the development of pulmonary embolism (PE) however there is limited data about role of thromboembolic events in OSA.
| Condition | Intervention |
|---|---|
|
Pulmonary Thromboembolism Obstructive Sleep Apnea |
Other: polysomnography |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Obstructive Sleep Apnea is Prevalent in Patients With Pulmonary Embolism |
| Enrollment: | 75 |
| Study Start Date: | November 2009 |
| Study Completion Date: | December 2010 |
| Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
Pulmonary embolism
Patients who were diagnosed with pulmonary embolism
|
Other: polysomnography
full night supervised laboratory polysomnography
Other Name: PSG
|
|
control group
age and sex matched adults with osa and no thromboembolism
|
Other: polysomnography
full night supervised laboratory polysomnography
Other Name: PSG
|
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
All subjects admitted to Department of Pulmonary Medicine of Gaziantep University who were diagnosed to have PE were included in the study group. Control group consisted of age and sex matched subjects without a clinic consistent with PE referred to the Sleep Clinic. PE was diagnosed when one or more of the following was present: compatible physical examination findings and multislice CT angiography or presence of deep venous thrombus (DVT) in addition to high risk with Wells criteria [5]. Subjects with any restrictive/obstructive lung pathology or younger than 18 years old were excluded.
Inclusion Criteria:
- All consecutive patients diagnosed with pulmonary embolism
Exclusion Criteria:
- less than 18 years of age
- any restrictive or obstructive lung disease
Contacts and Locations More Information
No publications provided
| Responsible Party: | meral uyar, Asisstant Professor, University of Gaziantep |
| ClinicalTrials.gov Identifier: | NCT01580085 History of Changes |
| Other Study ID Numbers: | gantep gogus 1 |
| Study First Received: | April 16, 2012 |
| Last Updated: | April 17, 2012 |
| Health Authority: | Turkey: Ministry of Health |
Keywords provided by University of Gaziantep:
|
Sleep disordered breathing gender hypercoagulability |
Additional relevant MeSH terms:
|
Apnea Embolism Pulmonary Embolism Sleep Apnea Syndromes Thromboembolism Sleep Apnea, Obstructive Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory Signs and Symptoms |
Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Lung Diseases Sleep Disorders, Intrinsic Dyssomnias Sleep Disorders Nervous System Diseases Thrombosis |
ClinicalTrials.gov processed this record on June 17, 2013