Post-exercise Recovery After Dietary Protein Ingestion in Healthy Young Men (Meat-Milk Study)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2012 by Maastricht University Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Stefan Gorissen, Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT01578590
First received: March 15, 2012
Last updated: June 11, 2012
Last verified: June 2012
  Purpose

Rationale: The consumption of dietary protein immediately after exercise is necessary to maximally stimulate muscle protein synthesis rates (24, 37). Recent work suggests that the type of protein consumed (e.g., animal vs. plant-derived proteins) during post-exercise recovery can affect the amplitude of acute increases in muscle protein synthesis rates (25, 31). Specifically, consumption of bovine milk proteins immediately after a single bout of resistance exercise stimulates muscle protein synthesis rates greater than consumption of an isonitrogenous soy-protein beverage (31, 37). Importantly, consumption of milk promotes greater hypertrophy than soy after resistance training (10). Thus, it is generally assumed that the acute muscle protein synthetic response predicts long-term training outcomes, such as hypertrophy. Currently, a great amount of work has been carried out to study the effects of consuming milk proteins on muscle protein synthesis rates after resistance exercise (5, 7, 26, 32). However, very little is known about the effects of other types of high-quality animal proteins, such as beef, on stimulating post-exercise muscle protein synthesis rates. Further describing the muscle protein synthetic response after consumption of other types of high-quality animal proteins will provide valuable information for individuals with milk allergies, lactose intolerance, or simply a strong dislike of dairy products.

Objective: To investigate whether the in vivo post-resistance exercise muscle protein synthetic response is augmented when minced beef is ingested as compared to an isonitrogenous-matched milk protein beverage in healthy young men.

Study design: Crossover, randomized

Study population: 12 healthy young males (18-35 y).

Intervention: Subjects will perform resistance exercise and consume either a piece of meat (135 grams, 35 g of protein) or an isonitrogenous-matched milk protein beverage on two separate test days. In addition, continuous intravenous tracer infusions will be applied, with plasma and muscle samples collected. A two week 'wash-out' period will be included between trials.

Main study parameters/endpoints Primary endpoint: Muscle protein synthetic rate, expressed as fractional synthetic rate (FSR). Secondary endpoints: Rate of protein digestion and absorption and whole body protein balance.


Condition Intervention
Skeletal Muscle Hypertrophy
Dietary Supplement: Lean minced meat (beef)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Supportive Care
Official Title: Post-exercise Recovery After Dietary Protein Ingestion in Healthy Young Men

Resource links provided by NLM:


Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Muscle protein synthetic rate, expressed as fractional synthetic rate (FSR) [ Time Frame: 1 day ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Rate of protein digestion and absorption and whole body protein balance [ Time Frame: 1 day ] [ Designated as safety issue: No ]

Estimated Enrollment: 12
Study Start Date: April 2012
Estimated Study Completion Date: April 2014
Estimated Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Subjects will consume lean minced meat
Subjects will perform resistance exercise and consume a piece of meat (135 grams, 35 g of protein)
Dietary Supplement: Lean minced meat (beef)
A piece of meat (135 grams, 35 g of protein) or an isonitrogenous-matched milk protein beverage
Other Names:
  • Meat
  • Milk
Active Comparator: Subjects will consume a milk beverage
Subjects will perform resistance exercise and consume a milk protein beverage
Dietary Supplement: Lean minced meat (beef)
A piece of meat (135 grams, 35 g of protein) or an isonitrogenous-matched milk protein beverage
Other Names:
  • Meat
  • Milk

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Males
  • Aged between 18-35 years
  • Healthy, recreationally active
  • BMI < 25 kg/m2

Exclusion Criteria:

  • Smoking
  • Allergies to milk proteins (whey or casein)
  • Vegetarians
  • Female
  • Arthritic conditions
  • A history of neuromuscular problems
  • Previous participation in amino acid tracer studies
  • Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01578590

Contacts
Contact: Stefan H Gorissen, MSc +31433881810 stefan.gorissen@maastrichtuniversity.nl

Locations
Netherlands
University of Maastricht Recruiting
Maastricht, Limburg, Netherlands, 6229 ER
Contact: Luc JC van Loon, PhD    +31433881397    l.vanloon@maastrichtuniversity.nl   
Sub-Investigator: Stefan H Gorissen, MSc         
Sub-Investigator: Nicholas A Burd, PhD         
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: Luc JC van Loon, Prof. Dr. Maastricht University
  More Information

No publications provided

Responsible Party: Stefan Gorissen, Principal Investigator, Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01578590     History of Changes
Other Study ID Numbers: METC 11-3-088
Study First Received: March 15, 2012
Last Updated: June 11, 2012
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Additional relevant MeSH terms:
Hypertrophy
Pathological Conditions, Anatomical

ClinicalTrials.gov processed this record on October 20, 2014