Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction
The aim of this study is to better discriminate respiratory muscle dysfunction by comparing the measurements of thoracoabdominal motion obtained by an optoelectronic recording and the conventional tests of respiratory muscle strength. The final objective is to better select in the future the patients who need more specific assessment of diaphragmatic function like "maximal transdiaphragmatic pressure" measurement and "phrenic nerve stimulation".
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Construction of a Database to Identify Early Indicators of Respiratory Muscle Dysfunction in Neuromuscular Patients From the Optoelectronic Plethysmography Assessment of the Thoracoabdominal Motion|
- compartmental distribution of the inspired/expired volumes [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
Measurements of the thoraco-abdominal motion and of the global lung volume changes.
Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and for each compartiment (upper thorax, lower thorax, abdomen) contribution of these volumes will be expressed in percentage.
- left side and right side contribution to the inspired/expired volumes [ Time Frame: 1 hour ] [ Designated as safety issue: No ]Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and each side contribution of these volumes will be expressed in percentage.
|Study Start Date:||June 2011|
|Estimated Study Completion Date:||January 2016|
|Estimated Primary Completion Date:||January 2016 (Final data collection date for primary outcome measure)|
respiratory muscle dysfunction patients
patients who present orthopnea, recruitment of accessory muscles, abdominal paradox, respiratory dysfunction or dyssynchronous movement
All patients which had suspected respiratory muscle dysfunction will have usual exploration of the respiratory muscles according to the clinician prescription. These explorations can include :
- Lung volumes in seating and supine position
- Maximal inspiratory and expiratory pressures
- Maximal sniff pressures
And when diaphragmatic dysfunction is suspected :
- Maximal transdiaphragmatic pressure
- Phrenic nerve conduction
These patients will also beneficiate to the determination of volume variations of the upper rib cage, the lower rib cage and the abdominal compartments by using Opto-electronic plethysmography.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01569217
|Contact: Frédéric LOFASO, MD-PhDfirstname.lastname@example.org|
|Raymond Poincaré Hospital||Recruiting|
|Garches, France, 92380|
|Contact: Frédéric Lofaso, MD PhD 33 1 47 10 79 41 email@example.com|
|Principal Investigator: Frédéric Lofaso, Professor|
|Principal Investigator:||Frédéric Lofaso, MD, PhD||Centre d'Investigation Clinique et Technologique 805|