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Effect of Water Rinsing After Topical Fluoride Application on Dental Plaque pH

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Fatemeh Mazhari, Mashhad University of Medical Sciences
ClinicalTrials.gov Identifier:
NCT01569165
First received: March 29, 2012
Last updated: March 30, 2012
Last verified: March 2012
History of Changes
  Purpose

The aim of this study was to determine whether rinsing with water or cleansing teeth after topical fluoride therapy affect the dental plaque pH.


Condition Intervention
Dental Caries
 Procedure: cleansing teeth after topical fluoride therapy

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Effect of Water Rinsing After APF Application on Dental Plaque Acidogenicity

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Mashhad University of Medical Sciences:

Primary Outcome Measures:
  • dental plaque PH [ Time Frame: the pH of 48-hour dental plaque was measured using plaque sampling method before (baseline pH) and after sucrose challenge at 5, 10,15,20,30 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • maximum pH drop [ Time Frame: 5,10,15,20 and 30 min after sucrose chalenge ] [ Designated as safety issue: No ]
  • pH recovery time [ Time Frame: within 30 min after sucrose challenge ] [ Designated as safety issue: No ]
    time for returning to the baseline pH


Enrollment: 25
Study Start Date: February 2011
Study Completion Date: November 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: washing after 30 min
washing with water after 30 min following APF treatment
 Procedure: cleansing teeth after topical fluoride therapy
washing with water 0, 15 or 30 min after APF treatment or cleansing teeth with cotton roll immediately following APF treatment.
Experimental: washing after 15 min
washing with water after 15 min following APF treatment
 Procedure: cleansing teeth after topical fluoride therapy
washing with water 0, 15 or 30 min after APF treatment or cleansing teeth with cotton roll immediately following APF treatment.
Experimental: immediately washing with water
immediately washing with water after APF treatment
 Procedure: cleansing teeth after topical fluoride therapy
washing with water 0, 15 or 30 min after APF treatment or cleansing teeth with cotton roll immediately following APF treatment.
Experimental: cleansing teeth with cotton roll
cleansing teeth with cotton roll immediately following APF treatment
 Procedure: cleansing teeth after topical fluoride therapy
washing with water 0, 15 or 30 min after APF treatment or cleansing teeth with cotton roll immediately following APF treatment.
No Intervention: no fluoride therapy
control group

  Eligibility

Ages Eligible for Study:   21 Years to 29 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy people (Without any systemic disease)
  • normal unstimulated salivary rate

Exclusion Criteria:

  • Active dental caries
  • taking any medication with any effect on saliva rate
  • taking antibiotic (or antibacterial mouth rinses) during last 4 weeks
  • usig fluoride mouth rinses during last 2 weeks.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01569165

Locations
Iran, Islamic Republic of
Dental School - Mashhad University of Medical Siences
Mashhad, Khorasan Razavi, Iran, Islamic Republic of
Sponsors and Collaborators
Mashhad University of Medical Sciences
Investigators
Principal Investigator: fatemeh mazhari, Associate Professor Mashhad University of Medical Siences
  More Information

No publications provided

Responsible Party: Fatemeh Mazhari, principal investigator, Mashhad University of Medical Sciences
ClinicalTrials.gov Identifier: NCT01569165     History of Changes
Other Study ID Numbers: 89629
Study First Received: March 29, 2012
Last Updated: March 30, 2012
Health Authority: Iran: Ethics Committee

Keywords provided by Mashhad University of Medical Sciences:
Acidogenicity
Acidulated phosphate fluoride
dental plaque
water rinsing

Additional relevant MeSH terms:
Dental Caries
Dental Plaque
Tooth Demineralization
Tooth Diseases
Stomatognathic Diseases
Dental Deposits
 Fluorides
Fluorides, Topical
Cariostatic Agents
Protective Agents
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on May 19, 2013