Training Dual-Task Walking After Stroke
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Purpose
Community ambulation is a highly complex skill requiring the ability to adapt to increased environmental complexity and perform multiple tasks simultaneously. Deficits in dual-tasking may severely compromise the ability to participate fully in community living. Unfortunately, current rehabilitation practice for stroke fails to adequately address dual-task limitations; individuals with stroke continue to exhibit clinically significant dual-task costs on gait at discharge. As a result, many stroke survivors are living in the community with residual deficits that may increase disability in the real world and lead to falls with devastating consequences. To address this issue, the proposed study investigates the efficacy of dual-task gait training on attention allocation and locomotor performance in community-dwelling stroke survivors. Because walking in the real world often requires time-critical tasks and obstacle avoidance, the investigators will test the impact of dual-task gait training on cognitive-motor interference during walking at preferred speed and at maximal speed (Aim 1), and on locomotor control during obstacle negotiation (Aim 2). The investigators will also evaluate the effects of the intervention on community reintegration and participation (Aim 3).
| Condition | Intervention |
|---|---|
|
Stroke |
Behavioral: Gait training |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single Blind (Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | Training Dual-Task Walking After Stroke: Effects on Attentional and Locomotor Control |
- Dual-task cost on gait speed [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]The dual-task cost represents the difference between single and dual-task walking speed.
- Executive function [ Time Frame: Measured at baseline, post intervention (4 weeks), 6 months post intervention ] [ Designated as safety issue: No ]A computerized version of the Stroop task will be used to assess changes in executive function.
- Spontaneous physical activity [ Time Frame: Measured at baseline, post intervention (4 weeks), 6 months post intervention ] [ Designated as safety issue: No ]Spontaneous physical activity will be assessed with an activity monitor (PAMSys) worn for two consecutive days at each assessment timepoint.
- Kinematics of gait during obstacle crossing [ Time Frame: Measured at baseline, post intervention (4 weeks), 6 months post intervention ] [ Designated as safety issue: No ]
- Stroke Impact Scale [ Time Frame: Measured at baseline, post intervention (4 weeks), 6 months post intervention ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 44 |
| Study Start Date: | September 2011 |
| Estimated Study Completion Date: | June 2015 |
| Estimated Primary Completion Date: | April 2015 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Dual-task gait training
Gait training with simultaneous performance of cognitive tasks for 75% of training session.
|
Behavioral: Gait training
Twelve 30-minute sessions plus 10-minute stretching and warm up, provided 3 times per weeks for 4 weeks. Up to 6 weeks are allowed to complete the 12 sessions.
|
| Active Comparator: Single-task gait training |
Behavioral: Gait training
Twelve 30-minute sessions plus 10-minute stretching and warm up, provided 3 times per weeks for 4 weeks. Up to 6 weeks are allowed to complete the 12 sessions.
|
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Within 12 months of stroke onset
- Living in the community, operationally defined as living in one's own home, or the home of a friend, relative, or caregiver
- Walking speed 0.6-1.1 m/s determined during 10-meter walk test
- Walk without the assistance of another person
- Medically stable and approved for participation by study physician
- Intact global cognition indicated by score > 23 on Montreal Cognitive Assessment
- Living in the community prior to stroke
Exclusion Criteria:
- Pre-existing neurological disorders (e.g., Parkinson's disease, Multiple Sclerosis, dementia, traumatic brain injury)
- Previous stroke with residual motor deficit
- Uncontrolled hypertension
- Inability to follow 3-step command
- Primary uncontrolled hearing impairment
- Severe uncontrolled visual impairment
- Any speech-language impairment affecting ability to respond verbally to auditory stimuli
- Timed Up and Go test > 15 seconds
- Lower extremity amputation
- Any orthopedic problem affecting gait
- Concurrent participation in another clinical trial
Contacts and Locations| Contact: Prudence Plummer-D'Amato, PhD | 617-373-7647 | pplummer@neu.edu |
| United States, Massachusetts | |
| Northeastern University | Recruiting |
| Boston, Massachusetts, United States, 02115 | |
| Contact: Prudence Plummer-D'Amato, PhD 617-373-7647 pplummer@neu.edu | |
| Principal Investigator: Prudence Plummer-D'Amato, PhD | |
| Sub-Investigator: Dagmar Sternad, PhD | |
| New England Rehabilitation Hospital | Recruiting |
| Woburn, Massachusetts, United States, 01801 | |
| Contact: Raymond Villalobos, MD 781-935-5050 rmvillalobos@me.com | |
| Contact: Keith Poulin, MPT 781-935-5050 kpoulin@5sqc.com | |
| Principal Investigator: Raymond Villalobos, MD | |
| Principal Investigator: | Prudence Plummer-D'Amato, PhD | Northeastern University |
More Information
No publications provided
| Responsible Party: | Prudence Plummer-D'Amato, Assistant Professor of Physical Therapy and Director, Neurocognitive Rehabilitation Research Laboratory, Northeastern University |
| ClinicalTrials.gov Identifier: | NCT01568957 History of Changes |
| Other Study ID Numbers: | 11SDG7270001 |
| Study First Received: | March 25, 2012 |
| Last Updated: | July 3, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Northeastern University:
|
Gait Dual-task Obstacle avoidance Attention allocation |
Additional relevant MeSH terms:
|
Stroke Cerebral Infarction Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases |
Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain Infarction Brain Ischemia |
ClinicalTrials.gov processed this record on May 23, 2013