Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes
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Purpose
There are controversial data about fluoride intake by children when tooth brushing with children's or regular toothpastes. However, a study have showed that children were exposed to a dose of 0.051 mg F/Kg/day and 0.046 mg F/kg/day by tooth brushing with children's and and regular toothpaste, respectively. Fluorides doses were too close and is questioned if there is a real clinical relevance in terms of risk of dental fluorosis. It is important to evaluate if children's toothpastes does really represent a risk of fluoride intake when compared to the regular toothpastes in terms of risk of dental fluorosis. The hypothesis is that both children's and regular toothpastes can represente risks of development of dental fluorosis and can represent similar fluoride exposure by children.
| Condition | Intervention |
|---|---|
|
Healthy Individuals |
Drug: Regular toothpastes Drug: Children's toothpastes |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Safety Study Intervention Model: Crossover Assignment Masking: Single Blind (Outcomes Assessor) Primary Purpose: Prevention |
| Official Title: | Fluoride Intake From Tooth Brushing With Children's and Regular Toothpastes: a Study With Preschooler Children |
- Evidence of mean dose of fluoride intake from tooth brushing with children's and regular toothpastes. [ Time Frame: One week interval between two tooth brushings ] [ Designated as safety issue: Yes ]
- Fluoride concentrations in toothpastes used by children. [ Time Frame: From date of toothpastes collection until laboratorial analysis, assessed up to 4 months ] [ Designated as safety issue: No ]
| Enrollment: | 208 |
| Study Start Date: | October 2007 |
| Study Completion Date: | March 2009 |
| Primary Completion Date: | July 2008 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: Children' toothpaste
Children's toothpastes
|
Drug: Regular toothpastes
One tooth brushing
|
|
Active Comparator: Regular toothpastes
Regular toothpastes
|
Drug: Children's toothpastes
One tooth brushing
|
Detailed Description:
Subjects: Children at age of development of dental fluorosis (up to 4 years) enrolled at day care centres from the city of Montes Claros (0.7 ppm F), Brazil.
The study design has two phases:
- In the first phase, children are required to bring at the day care centres the tooth brush and the toothpaste used at home. There is no randomization, since the inclusion in either children's or regular toothpaste groups will be done based on each child's preference. The children are requested to tooth brush as the usual manner that the parent and the child do at home. Saliva expectorates are collected as the protocol described by Guha-Chowdhury et al. (1996). No instructions are provided in this phase or interventions by the researcher. Saliva expectorates are collected for further laboratory analysis. Toothpastes are collected for laboratory analysis.
- In the second phase, children are required to toothbrush with other type of toothbrush following the same tooth brushing protocol. For example, children that previously used children's toothpaste will be provided a regular toothpaste, and vice-versa.
Parents are requested to answer a questionnaire regarding their children's tooth brushing habits and socioeconomic factors.
Laboratory analysis provides estimation of fluoride intake from tooth brushing with both toothpastes.
Analysis will base on dose of fluoride intake (mg F/Kg body weight/day) considering children's and regular toothpastes.
Eligibility| Ages Eligible for Study: | 6 Months to 48 Months |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Consent demonstrates understanding of the study and willingness to participate as evidenced by voluntary written of informed consent and has received a signed and dated copy of the informed consent form.
- Age up to 48 months.
- Compliance understands of the study and ability to comply with the study procedures.
- Good oral health as considered by the investigator.
- Good general health as considered by the investigator, with no clinically significant and/or relevant abnormalities of medical history.
Exclusion Criteria:
- Children aging older than 48 months or younger of 6 months.
- Parents who do not allow the child's participation.
- Children that refuse to follow the study procedure.
- Volunteers that do not complete the whole study protocol.
Contacts and Locations| Brazil | |
| Universidade Federal de Minas Gerais | |
| Belo Horizonte, Minas Gerais, Brazil, 31270-901 | |
| State University of Montes Claros | |
| Montes Claros, Minas Gerais, Brazil, 39401-089 | |
| Piracicaba School of Dentistry of State University of Campinas | |
| Piracicaba, São Paulo, Brazil, 13414-903 | |
| Principal Investigator: | Carolina C Martins, PhD | Federal University of Minas Gerais |
More Information
Additional Information:
Publications:
| Responsible Party: | Carolina Castro Martins, Principal Investigator, Federal University of Minas Gerais |
| ClinicalTrials.gov Identifier: | NCT01568541 History of Changes |
| Other Study ID Numbers: | NCT17591320 |
| Study First Received: | March 28, 2012 |
| Last Updated: | September 14, 2012 |
| Health Authority: | Brazil: National Committee of Ethics in Research |
Keywords provided by Federal University of Minas Gerais:
|
children dentifrice fluoride dental fluorosis |
Additional relevant MeSH terms:
|
Fluorides Cariostatic Agents Protective Agents Physiological Effects of Drugs Pharmacologic Actions |
ClinicalTrials.gov processed this record on May 21, 2013