Insecticidal School Uniforms for Dengue Prevention in Thailand (DengueTools)

This study is enrolling participants by invitation only.
European Union
Information provided by (Responsible Party):
Peter Byass, Umeå University Identifier:
First received: March 16, 2012
Last updated: March 30, 2012
Last verified: March 2012

This is a randomised controlled trial that will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-15 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent high quality of insecticide impregnation with permethrin. A double-blind randomised cross-over trial at the school level will cover two dengue transmission seasons.

Condition Intervention
Other: permethrin insecticide
Other: washing

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Can Insecticide-treated School Uniforms Reduce Dengue Infections in School-aged Children in Thailand

Resource links provided by NLM:

Further study details as provided by Umeå University:

Primary Outcome Measures:
  • insecticide:placebo incidence rate-ratio (per 1,000 person-years) of laboratory-confirmed dengue cases in school-aged children [ Time Frame: up to 2 years ] [ Designated as safety issue: No ]
    Schools are cross-over randomised to insecticide-treated or untreated (placebo) school uniforms, and so the primary outcome is the rate-ratio of dengue fever cases in school children, compared between these two groups.

Secondary Outcome Measures:
  • comparison between intervention and placebo groups of number of serious skin reactions to insecticide-treated uniforms [ Time Frame: up to 2 years ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 2300
Study Start Date: March 2012
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: normal school uniforms Other: washing
normal washing of school uniforms
Experimental: insecticide-treated school uniforms Other: permethrin insecticide
commercial impregnation of clothing before transmission season


Ages Eligible for Study:   7 Years to 15 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • pupils in participating schools

Exclusion Criteria:

  • skin sensitivity, exema
  Contacts and Locations
Please refer to this study by its identifier: NCT01563640

Centre of Excellence for Vectors and Vector-Borne Diseases, Mahidol University
Salaya, Thailand
Sponsors and Collaborators
Umeå University
European Union
Principal Investigator: Annelies Wilder-Smith, MD Umeå University
  More Information

Additional Information:
No publications provided by Umeå University

Additional publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Peter Byass, Professor of Global Health, Umeå University Identifier: NCT01563640     History of Changes
Other Study ID Numbers: 282589-T
Study First Received: March 16, 2012
Last Updated: March 30, 2012
Health Authority: Thailand: Ethical Committee

Keywords provided by Umeå University:

Additional relevant MeSH terms:
Arbovirus Infections
Virus Diseases
Flavivirus Infections
Flaviviridae Infections
RNA Virus Infections
Hemorrhagic Fevers, Viral
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions processed this record on April 17, 2014