Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2012 by The University of Hong Kong.
Recruitment status was  Not yet recruiting
Sponsor:
Collaborator:
Queen Mary Hospital, Hong Kong
Information provided by (Responsible Party):
The University of Hong Kong
ClinicalTrials.gov Identifier:
NCT01563016
First received: March 22, 2012
Last updated: March 23, 2012
Last verified: March 2012
  Purpose

The research aims to investigate the relationship between self-control ability and blood glucose level in schizophrenic patients. The main purpose of the present study is to explore whether the close relationship of blood glucose and self-regulatory strength observed in healthy individuals, is applicable to schizophrenic patients. More specifically, the current study aims

  • to investigate whether the exertion of self-control reduces blood glucose,
  • to examine whether low level of blood glucose deteriorates subsequent self-control performances
  • to examine whether restoring the glucose level eliminates these impairments, in schizophrenic patients.

Condition Intervention
Schizophrenia
Dietary Supplement: glucose drink

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia: A Randomized Controlled Study

Resource links provided by NLM:


Further study details as provided by The University of Hong Kong:

Primary Outcome Measures:
  • Blood Glucose Level [ Time Frame: baseline, after depleting task ] [ Designated as safety issue: No ]
  • self control tasks (handgrip, stroop, figure tracing task) [ Time Frame: after 12-minutes metabolizing phase ] [ Designated as safety issue: No ]

Estimated Enrollment: 100
Study Start Date: April 2012
Estimated Study Completion Date: April 2013
Estimated Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Glucose & Depleting
participants will perform in a depleting task and receive a glucose drink
Dietary Supplement: glucose drink
participants will receive a drink rich in glucose
Placebo Comparator: Glucose & non-depleting
participants will perform in a non-depleting task and receive a glucose drink
Dietary Supplement: glucose drink
participants will receive a drink rich in glucose
No Intervention: Placebo & depleting
participants will perform in a depleting task and receive a placebo drink
No Intervention: Placebo & non depleting
participants will perform in a non depleting task and receive a placebo drink

  Eligibility

Ages Eligible for Study:   15 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Aged 15 or above
  • DSM-IV diagnosis of schizophrenia, schizoaffective disorder, schizophreniform psychosis, brief psychosis, psychosis NOS or delusional disorder
  • Cantonese-speaking Chinese
  • Ability to understand the nature of the study and sign informed consent

Exclusion Criteria:

  • Organic Brain disorder
  • Known history of intellectual disability
  • Priority Follow Up (Subtarget or Target)
  • All allergic to any sugar or artificial sweeteners
  • Diabetics
  • Physical Disability
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01563016

Contacts
Contact: Eric YH Chen, MD 852-22553063 eyhchen@hku.hk
Contact: Chung-Ming Leung, Bsc 852-64054460 mingming4f29@hotmail.com

Locations
China
The University of Hong Kong Not yet recruiting
Hong Kong, China
Contact: Bonnie Choi       bwschoi@hku.hk   
Sponsors and Collaborators
The University of Hong Kong
Queen Mary Hospital, Hong Kong
Investigators
Principal Investigator: Eric YH Chen, MD The University of Hong Kong
  More Information

No publications provided

Responsible Party: The University of Hong Kong
ClinicalTrials.gov Identifier: NCT01563016     History of Changes
Other Study ID Numbers: selfcontrolvsglucose
Study First Received: March 22, 2012
Last Updated: March 23, 2012
Health Authority: Hong Kong: Ethics Committee

Keywords provided by The University of Hong Kong:
schizophrenia
Psychotic Disorders
Psychoses

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on September 15, 2014