Study of LY2886721 in Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease

Inclusion Criteria:

Meets criteria for MCI due to AD or Mild AD

All participants will be required to undergo assessment via the Mini Mental State Examination (MMSE) scale at screening

• Participants with MMSE scores of 20 to 26, inclusive, may be enrolled provided they meet the criteria for mild AD, as follows:

  • Participant meets the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS/ADRDA) criteria for probable AD;
  • Clinical Dementia Rating Scale (CDR) score of 0.5 or 1
  • Positive scan for the presence of amyloid beta

• Participants with MMSE of 27 to 30, inclusive, may be enrolled as participants with MCI due to AD provided they meet the following criteria:

  • Gradual and progressive change in memory function as reported by the participant or a caregiver during a period of more than 6 months;
  • Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR): free recall ≤22 and total recall ≤46;
  • Absence of dementia;
  • Preservation of functional independence;
  • Exclusion of other potential (vascular, traumatic, or medical) causes of cognitive decline, where possible;
  • Positive scan for the presence of amyloid beta
• Women must be postmenopausal
• Men are required to use an approved barrier method of contraception if their partners are pregnant, or of childbearing potential and not using approved contraceptive methods

Exclusion Criteria:

• Participant in another drug or device study
• Have a history of frontotemporal dementia, Lewy body disease, vascular dementia, Huntington's disease or Parkinson's disease, progressive supranuclear palsy (PSNP) or other movement disorder
• Participants are not on a stable standard of care (acetylcholinesterase inhibitors, memantine) initiated less than two months prior to entry or have less than 4 weeks of stable therapy. Note: Stable standard of care is allowed
• Have had a serious infectious disease affecting the brain in the past 5 years
• Have had a serious or repeat head injury
• Have significant retinal impairment or disease
• Have had a stroke or other circulation problems that are affecting your current health
• Have had a seizure
• Have major depressive disorder and are not on a stable dose of medication. Participants who no longer meet the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-Text Revision (DSM-IV) criteria for major depression may be included
• History of schizophrenia, bipolar disorder or severe mental illness.
• History of alcohol or drug abuse
• Have asthma, chronic obstructive pulmonary disease (COPD) or other breathing disease that is not controlled with medicine
• Have human immunodeficiency virus (HIV) or syphilis
• Are taking blood thinners