Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment

This study has been completed.
Sponsor:
Collaborators:
ShiYan Centre for Disease Control and Prevention
Tufts Medical Center
Information provided by (Responsible Party):
Xiufa Sun, Huazhong University of Science and Technology
ClinicalTrials.gov Identifier:
NCT01559766
First received: March 19, 2012
Last updated: March 20, 2012
Last verified: March 2012
  Purpose

Vitamin A deficiency remains a major public health problem in developing country worldwide. Young Children are considered to be at greatest risk of deficiency. However, there is little information on the vitamin A requirement of Chinese children. In the present study, about 400 children aged between 4 and 9 years old in a kindergarten and an elementary school of Shiyan City were screened before admission by questionnaire and anthropometric measurement. The vitamin A status of children was assessed by serum vitamin A level, relative dosage reaction and stable-isotope dilution technique. At the same time, their dietary vitamin A intakes were estimated by weighted-food dietary survey. The dietary vitamin A requirement in young children was determined on the basis of dietary vitamin A intakes in Children with adequate vitamin A level.


Condition
Vitamin A Deficiency

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Estimating Dietary Vitamin A Requirement in Chinese Children by Stable-isotope Dilution Technique

Resource links provided by NLM:


Further study details as provided by Huazhong University of Science and Technology:

Biospecimen Retention:   Samples Without DNA

serum


Enrollment: 403
Study Start Date: July 2009
Study Completion Date: September 2010
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
4-6 years old group
7-9 years old group

  Eligibility

Ages Eligible for Study:   4 Years to 9 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The study was carried out in a kindergarten and an elementary school in Shiyan city, Hubei province of China. Initially, 201 kindergarten children (4-6 years old) and 202 grade children (7-9 years old) were subjected to a questionnaire survey on personal information, medical history and dietary habits including dietary supplements.ongoing or previous illnesses, having taken nutritional supplements within 3 months, positive results in the fat absorption test or parasite test, increased level of CRP (> 8 mg/L), or lower serum level of retinol (<1.40 umol/L), and higher ratio in relative dosage reaction test(>20%) .After the screening, 123 children were selected and completed the study, but 60 subjects were randomly selected for the DRD test to evaluate liver vitamin A storage.

Criteria

Inclusion Criteria:

  • well-nourished children with normal serum retinol(>=1.40umol/L)

Exclusion Criteria:

  • ongoing or previous illnesses,
  • having taken nutritional supplements within 3 months,
  • positive results in the fat absorption test or parasite test,
  • increased level of CRP (> 8 mg/L), or
  • lower serum level of retinol (< 1.40 umol/L)
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01559766

Locations
China, Hubei
Shiyan Centre for Disease Control and Prevention
Shiyan, Hubei, China, 442500
Sponsors and Collaborators
Huazhong University of Science and Technology
ShiYan Centre for Disease Control and Prevention
Tufts Medical Center
Investigators
Principal Investigator: Xiufa Sun, BS Tongji Medical College, Huazhong University of Science and Technology
  More Information

No publications provided

Responsible Party: Xiufa Sun, Professor, Huazhong University of Science and Technology
ClinicalTrials.gov Identifier: NCT01559766     History of Changes
Other Study ID Numbers: No.2008BAI58B03
Study First Received: March 19, 2012
Last Updated: March 20, 2012
Health Authority: China: Ministry of Science and Technology

Keywords provided by Huazhong University of Science and Technology:
Vitamin A
Dietary requirement
Dietary records
Deuterated retinol dilution technique
Chinese children
Dietary intake of vitamin A
Vitamin A liver reserves

Additional relevant MeSH terms:
Vitamin A Deficiency
Night Blindness
Avitaminosis
Deficiency Diseases
Malnutrition
Nutrition Disorders
Vision Disorders
Eye Diseases
Vitamin A
Vitamins
Retinol palmitate
Micronutrients
Growth Substances
Physiological Effects of Drugs
Pharmacologic Actions
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents
Anticarcinogenic Agents
Antineoplastic Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on April 23, 2014