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Mechanical Alternans Study (MAS)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Larisa Tereshchenko, Johns Hopkins University Identifier:
First received: March 16, 2012
Last updated: August 14, 2013
Last verified: August 2013

The purpose of this study is to determine whether mechanical alternans (alternating strong and weak heart beats with a constant beat-to-beat interval), can be used to predict malignant ventricular arrhythmias, requiring defibrillation or appropriate ICD therapies, and to predict progression of heart failure and death.

Ischemic Cardiomyopathy
Nonischemic Cardiomyopathy
Heart Failure

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Study of Mechanical Alternans for Prediction of Ventricular Tachyarrhythmias

Resource links provided by NLM:

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • sudden arrhythmic death [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
    appropriate ICD therapy due to fast ventricular tachycardia or ventricular fibrillation, or sudden cardiac death

Secondary Outcome Measures:
  • cardiovascular mortality [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
  • all-cause death [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
  • appropriate ICD therapies [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
    either ICD shock or antitachycardia pacing due to ventricular arrhythmia

  • composite heart failure endpoint [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
    pump-failure death, or heart transplantation, or heart failure hospitalization, whichever came first

Estimated Enrollment: 1000
Study Start Date: November 2009
Estimated Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients with structural heart disease, ischemic or non-ischemic cardiomyopahty


Inclusion Criteria:

  • structural heart disease
  • ischemic or non-ischemic cardiomyopathy

Exclusion Criteria:

  • pregnancy
  • age < 18 years old
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01557465

United States, Maryland
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
Johns Hopkins University
  More Information

No publications provided by Johns Hopkins University

Additional publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Larisa Tereshchenko, Instructor of Medicine, Johns Hopkins University Identifier: NCT01557465     History of Changes
Other Study ID Numbers: NA_00032758
Study First Received: March 16, 2012
Last Updated: August 14, 2013
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Heart Failure
Cardiovascular Diseases
Heart Diseases processed this record on November 20, 2014