STA9090: Phase I Trial of Ganetespib, Capecitabine, and Radiation in Rectal Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by Emory University
Sponsor:
Collaborator:
Synta Pharmaceuticals Corp.
Information provided by (Responsible Party):
Bassel El-Rayes, Emory University
ClinicalTrials.gov Identifier:
NCT01554969
First received: March 13, 2012
Last updated: March 14, 2014
Last verified: March 2014
  Purpose

The purpose of this study is to find out what effects, good and/or bad, the combination of the study drug, capecitabine and radiation have on you and your cancer. Capecitabine, radiation and the study drug kill cancer cells in different ways. Giving these treatments together may make your cancer shrink or slow down its growth more than it would if you got treated with capecitabine and radiation alone.

This is a Phase I, drug study of ganetespib given together with capecitabine and radiation in patients with locally advanced rectal cancer. Ganetespib is an experimental drug; not approved by the Food and Drug Administration (FDA). The other two capecitabine and radiation are approved by FDA for use in rectal cancer.

In this study, the investigators will test different dosages of the "investigational" (experimental) drug, called ganetespib (the study drug). The study drug is "investigational" because it is not approved by the FDA for use. The study drug has been previously tested in humans. The study uses a well-established process of slowly increasing drug dosage to determine the highest dosage that can be given without causing serious side effects. In addition, the study will help researchers to determine what the side effects and drug interactions might be.

The study will also look at the drug's pharmacokinetics (PK). PK is how the study drug and capecitabine with radiation work in your body (for example how long the drugs last in your body.)


Condition Intervention Phase
Rectal Cancer
Drug: capecitabine +ganetespib
Phase 1

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: STA9090: Phase I Trial of Ganetespib, Capecitabine, and Radiation in Rectal Cancer

Resource links provided by NLM:


Further study details as provided by Emory University:

Primary Outcome Measures:
  • Tumor response and disease progression will be evaluated in this study using the international criteria proposed by the RECIST. [ Time Frame: 8 weeks ] [ Designated as safety issue: Yes ]
    Changes in only the largest diameter (unidimensional measurement) of the tumor lesions are used in the RECIST criteria.


Estimated Enrollment: 24
Study Start Date: May 2012
Estimated Study Completion Date: November 2015
Estimated Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: capecitabine + ganetespib .
Capecitabine oral medication. Ganetespib IV medication
Drug: capecitabine +ganetespib

Capecitabine will be started on Day 1 of the concurrent chemo-radiation phase at the specified dose, and is given orally twice daily for the entire duration of radiation therapy

in all patients, ganetespib monotherapy will be given up to 2 weeks prior to start of concurrent chemoradiation. Sequential biopsies will be taken at baseline and prior to the start of concurrent chemoradiation. In the dose escalation part of the study, the starting does of ganetespib is 60mg/m2 once weekly, and capecitabine at a dose of 825 mg/m2 twice daily.

Other Names:
  • Ganetespib
  • STA-9090

Detailed Description:

Patients with rectal cancer who meet the eligibility criteria will be offered to enroll on the study. As part of the study patients will receive the standard of care capecitabine (825 mg/m2 by moth twice daily) and radiation. Patients will start on ganetespib (STA9090) at a set dose level.

The treatment consists of two parts. In the first part patients will receive ganetespib at full dose twice a week through the vein for two weeks. At the end of two weeks, a biopsy of the tumor will be performed to evaluate the effect of the drug on the tumor. In the second phase, the patients will receive capecitabine, radiation and ganetespib at a specified dose level for 5 to 6 weeks. After completion of this phase patient will have surgery to remove the tumor. Each three patients will be treated at a specified dose level. Patients will be monitored at least once a week for side effects. If there are no side effects in three consecutive patients then the investigators will treat the next three patients at a higher dose level.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Must be at least 18 years of age
  • Stage II or III histologically-proven rectal adenocarcinoma. The distal border of the tumor must be at or below the peritoneal reflection, defined as within 12 centimeters of the anal verge by proctoscopic examination.
  • ECOG Performance Status 0 or 1
  • Adequate hematologic function as defined by:

    • Absolute neutrophil count > 1,500 cells/µL
    • Platelets >100,000/µL
    • Hemoglobin> 9.0g/dL
  • Adequate hepatic function as defined by:

    • Total bilirubin < 1.5 x the upper limit of normal (ULN)
    • AST and alanine aminotransferase (ALT) < 2.5 x ULN
    • Albumin 3.0 g/dL
  • Adequate renal function as defined by:

    • Serum creatinine 1.5 x ULN
    • Calculated creatinine clearance of 50 mL/min
  • INR ≤ 1.5. Anticoagulation is allowed only with low molecular weight heparin (LMWH). Patient receiving LMW heparin on stable therapeutic dose for more than 2 weeks or with factor Xa level < 1.1U/mL are allowed on the trial.
  • Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures
  • Ability to understand and willingness to sign a written informed consent document
  • Female subjects of childbearing potential and males must agree to use adequate contraception (e.g., hormonal or barrier method of birth control; abstinence) for the duration of study treatment
  • Female subjects of childbearing age must have a negative serum pregnancy test at study entry.

Exclusion Criteria

  • History of previous radiation therapy to the abdomen or pelvis
  • History of previous chemotherapy for rectal cancer
  • Major surgery within 4 weeks prior to first dose of ganetespib
  • Poor venous access for study drug administration. The study drug must be administered via peripheral venous access or through vascular access devices (VADs) (such as ports and peripherally-inserted central catheters [PICCS] containing silicone catheters. Use of VADs with catheters made of any other material is not allowed.
  • History of severe allergic or hypersensitivity reactions to excipients (e.g., Polyethylene glycol [PEG] 300 and Polysorbate 80)
  • Baseline QTc > 450 msec or previous history of QT prolongation while taking other medications
  • Ventricular ejection fraction (Ef)> 55% at baseline
  • Treatment with chronic immunosuppressants (e.g., cyclosporine following transplantation)
  • Women who are pregnant or lactating
  • Uncontrolled intercurrent illness
  • Other medications, or severe acute/chronic medical or psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the subject inappropriate for entry into this study
  • Patients must be able to take oral medications.
  • Unequivocal metastatic disease on computed tomography or chest X-ray
  • Clinically significant comorbid conditions such as cardiovascular disease or significant peripheral vascular (e.g., uncontrolled hypertension, myocardial infarction, unstable angina) within 6 months of study entry, serious cardiac arrhythmia requiring medication, and uncontrolled infection.
  • Clinical evidence of bleeding diathesis or coagulopathy
  • Significant involvement of the bladder by the tumor
  • Patients with prior malignancies, including pelvic cancer, are eligible if they have been disease free for > 5 years. Patients with prior in situ carcinomas are eligible provided there was complete removal.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01554969

Contacts
Contact: Bassel El-Rayes, MD belraye@emory.edu

Locations
United States, Georgia
Emory University Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Bassel El-Rayes    404-778-1900    belraye@emory.edu   
Principal Investigator: Bassel El-Rayes, MD         
Sponsors and Collaborators
Emory University
Synta Pharmaceuticals Corp.
Investigators
Principal Investigator: Bassel El-Rayes, MD Emory University
  More Information

No publications provided by Emory University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Bassel El-Rayes, Principal Investigator, Emory University
ClinicalTrials.gov Identifier: NCT01554969     History of Changes
Other Study ID Numbers: IRB00054181, STA 9090
Study First Received: March 13, 2012
Last Updated: March 14, 2014
Health Authority: United States: Institutional Review Board
United States: Food and Drug Administration

Additional relevant MeSH terms:
Rectal Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Intestinal Diseases
Rectal Diseases
Capecitabine
Fluorouracil
Antimetabolites, Antineoplastic
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Antineoplastic Agents
Therapeutic Uses
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on August 28, 2014