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Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal (SchistoVAN)

This study has been completed.
Sponsor:
Collaborators:
Institut Pasteur de Lille
Université de Lille Nord de France
Région Nord-Pas de Calais, France
Center for Infection and Immunity of Lille, France
France: Centre National de la Recherche Scientifique
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
Biomedical Research Center EPLS
ClinicalTrials.gov Identifier:
NCT01553552
First received: March 12, 2012
Last updated: March 13, 2012
Last verified: March 2012
  Purpose

SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their haemoglobinaemia.


Condition
Schistosomiasis
Anemia
Underweight
Stunting
Intestinal Parasites

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Comparison of Schistosomiasis Diagnostic Techniques and Study of Schistosoma Infection on Children's Immune Response to Childhood Vaccines, on Anaemia and on Nutritional Status

Resource links provided by NLM:


Further study details as provided by Biomedical Research Center EPLS:

Biospecimen Retention:   Samples Without DNA

Whole blood Sera Urine Stool


Enrollment: 99
Study Start Date: October 2011
Study Completion Date: October 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
Infected by Schistosoma haematobium
Not infected by Schistosoma haematobium

Detailed Description:

SchistoVAN aims to study the interactions between chronic parasite infections such as schistosomiasis and the immunological and nutritional status of children. In this scope, the investigators conducted a case-control study where one group of children is infected with schistosoma haematobium and the other is not infected with this parasite.

The investigators then stimulated whole blood of these children with various vaccine antigens to address their immune function and study the influence of schistosomiasis infectious state on their overall immune condition.

Aims of the study:

To evaluate the interaction between schistosomiasis and the nutritional status of children and their haemoglobinemia.

To evaluate the influence of schistosomiasis on children's specific immune response towards EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.

To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary dipsticks)

To study prevalence of intestinal parasites such as Blastocystis hominis

  Eligibility

Ages Eligible for Study:   6 Years to 10 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Residents of 3 villages from the Senegal Valley River, belonging to the Podor District in Saint-Louis Region in Northern Senegal: Agniam Towguel, Fanaye Diery and Niandane. Subcohort of a previous study "AnoPalAnoVac" (ClinicalTrials.gov ID: NCT01545115)

Criteria

Inclusion Criteria:

  • Members of AnoPalAnoVac cohort
  • Age: between 6 and 10 years

Exclusion Criteria:

  • body temperature > 38.5 ºC
  • malaria episode
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01553552

Locations
Senegal
Biomedical Research Center EPLS
Saint-Louis, SL, Senegal
Sponsors and Collaborators
Biomedical Research Center EPLS
Institut Pasteur de Lille
Université de Lille Nord de France
Région Nord-Pas de Calais, France
Center for Infection and Immunity of Lille, France
France: Centre National de la Recherche Scientifique
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
Study Chair: Emmanuel Hermann, PhD A.Pr. Biomedical Research Center EPLS
Study Director: Lobna Gaayeb, VetMed Biomedical Research Center EPLS
Principal Investigator: Modou Seck, MD Biomedical Research Center EPLS
  More Information

Additional Information:
No publications provided

Responsible Party: Biomedical Research Center EPLS
ClinicalTrials.gov Identifier: NCT01553552     History of Changes
Other Study ID Numbers: EPLS11-MS
Study First Received: March 12, 2012
Last Updated: March 13, 2012
Health Authority: Senegal: Ministere de la sante

Keywords provided by Biomedical Research Center EPLS:
Schistosoma haematobium
schistosoma mansoni
Anemia
Underweight
stunting
Blastocystis

Additional relevant MeSH terms:
Anemia
Intestinal Diseases, Parasitic
Schistosomiasis
Digestive System Diseases
Gastrointestinal Diseases
Helminthiasis
Hematologic Diseases
Intestinal Diseases
Parasitic Diseases
Trematode Infections

ClinicalTrials.gov processed this record on November 24, 2014