Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors
RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer.
PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.
Genetic: DNA analysis
Genetic: fluorescence in situ hybridization
Genetic: gene expression analysis
Genetic: gene mapping
Genetic: microarray analysis
Genetic: polymerase chain reaction
Genetic: protein expression analysis
Other: laboratory biomarker analysis
Other: medical chart review
|Official Title:||Endogenous DNA Transposition in Rhabdoid Tumors|
- Expression and function of PGBD5 in rhabdoid tumors [ Designated as safety issue: No ]
|Study Start Date:||March 2012|
|Estimated Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
- To investigate the expression and function of PGBD5 in 50 primary rhabdoid tumors.
OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of PGBD5. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.
|Principal Investigator:||Elizabeth A. Mullen, MD||Dana-Farber Cancer Institute|