EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia
The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness. While under general anesthesia your brain waves will be measured using electroencephalogram (EEG). On a separate day, the patient's brain will be imaged using magnetic resonance imaging (MRI).
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Electroencephalogram Studies of Induction and Recovery From Propofol Induced General Anesthesia|
- Localize and track brain activity under propofol sedation. [ Time Frame: 11 hours ] [ Designated as safety issue: No ]The primary goal of this trial is to localize and track changes in brain activity during loss and recovery of consciousness induced by propofol using source localization from EEG recordings analyzed with spectral methods, source localizations techniques and event-related potentials.
|Study Start Date:||August 2005|
|Estimated Study Completion Date:||July 2015|
|Estimated Primary Completion Date:||July 2015 (Final data collection date for primary outcome measure)|
Experimental: Active Study Arm
Subjects recruited into this study will be required to undergo a base MRI scan of the brain. On a separate day propofol will be administered with concurrent EEG while subjects respond to stimuli.
Propofol will be infused using a computer controlled delivery system running the program STANPUMP. Loss of consciousness will be defined as loss of response to auditory stimulus (button press).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01543633
|United States, Massachusetts|
|Massachusetts General Hospital|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Emery N Brown, M.D., Ph.D.||Massachusetts General Hospital|