Analysis of GERD Symptoms Using Gastroesophageal Reflux Impact Score Questionnaire for Quality of Life
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Purpose
Even the patients complain GERD symptoms such as heartburn and acid regurgitation the final diagnosis could be reflux esophagitis (RE), non-erosive reflux disease (NERD) and even functional heartburn (FH). In addition, the GERD symptoms are consisted of esophageal symptoms and extraesophageal symptoms. Thus it is necessary to use effective tool for the measurement of GERD symptoms and response of proton pump inhibitor in short time. Several questionnaires have been made for the assessment of GERD symptoms in recent years However, their screening tools do not include the impact of symptoms on everyday life and take a long time to complete the questionnaires. The GERD impact scale (GIS) questionnaire has been developed to compensate for this. It is a simple, one-page, questionnaire to communicate to the doctor the frequency of reflux symptoms and their effect on quality of life, recognizing that it might also prompt clinicians to make appropriate treatment for patients' symptoms. However, there was no report regarding comparison of the characteristics and response to PPI in RE, NERD and FH groups using GIS questionnaire so far.
| Condition |
|---|
|
Reflux Esophagitis (RE) Non-erosive Reflux Disease (NERD) Functional Heartburn (FH) |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Retrospective |
| Official Title: | Comparison of Risk Factors, GERD Symptoms and PPI Responses in the Reflux Esophagitis, Non-erosive Reflux Disease and Functional Heartburn Using GERD Impact Scale Questionnaire |
- The GIS score at baseline [ Time Frame: Before 8 weeks PPI treatment(baseline) ] [ Designated as safety issue: No ]
- Change of the GIS score from baseline [ Time Frame: After 8 weeks PPI treatment ] [ Designated as safety issue: No ]
| Enrollment: | 207 |
| Study Start Date: | July 2008 |
| Groups/Cohorts |
|---|
| Reflux esophagitis (RE) |
| Non-erosive reflux disease (NERD) |
| Functional heartburn (FH) |
Eligibility| Ages Eligible for Study: | 16 Years to 85 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Even the patients complain GERD symptoms such as heartburn and acid regurgitation the final diagnosis could be reflux esophagitis (RE), non-erosive reflux disease (NERD) and even functional heartburn (FH).
Inclusion Criteria:
- Adult Subjects (From 16 to 85 years old)
- The subjects with GERD symptom who received 8 week PPI therapy
Exclusion Criteria:
- Patients with a history of gastrointestinal surgery, Barrett's esophagus, esophageal motility disorder, duodenal ulcer, benign gastric ulcer or gastroduodenal cancer and systemic disease requiring chronic medication (except for hypertension and diabetes mellitus)
- Patients who took H2 blocker or a PPI to relieve these symptoms within 4 weeks
Contacts and Locations More Information
No publications provided
| Responsible Party: | Nayoung Kim, Professor, M.D., Seoul National University Bundang Hospital |
| ClinicalTrials.gov Identifier: | NCT01536080 History of Changes |
| Other Study ID Numbers: | D9612L00150 |
| Study First Received: | February 13, 2012 |
| Last Updated: | February 15, 2012 |
| Health Authority: | South Korea: Institutional Review Board |
Additional relevant MeSH terms:
|
Esophagitis Esophagitis, Peptic Gastroesophageal Reflux Heartburn Esophageal Diseases Gastrointestinal Diseases Digestive System Diseases |
Gastroenteritis Peptic Ulcer Esophageal Motility Disorders Deglutition Disorders Signs and Symptoms, Digestive Signs and Symptoms |
ClinicalTrials.gov processed this record on May 21, 2013