Single Arm Study of RAD001 as Monotherapy in Treatment in Advanced Cholangiocarcinoma (CRAD001T)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by Ratchavithi Hospital.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by (Responsible Party):
Kawin Leelawat, Ratchavithi Hospital
ClinicalTrials.gov Identifier:
NCT01525719
First received: January 31, 2012
Last updated: February 2, 2012
Last verified: January 2012
  Purpose

The purpose of this study is to determine whether everolimus is effective in the treatment of patients with advance cholangiocarcinoma.


Condition Intervention Phase
Cholangiocarcinoma
Drug: Everolimus
Phase 2

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase II Single Arm Study to Evaluate the Safety and Efficacy of RAD001 as Monotherapy in Treatment naïve Advanced Cholangiocarcinoma

Resource links provided by NLM:


Further study details as provided by Ratchavithi Hospital:

Primary Outcome Measures:
  • progression free survival in cholangiocarcinoma patients whom treated with everolimus [ Time Frame: One year ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • overall survival rate [ Time Frame: Two years ] [ Designated as safety issue: No ]
    Overall survival is defined as the time from dater of start of treatment to date of death due to any cause.


Estimated Enrollment: 40
Study Start Date: January 2012
Estimated Study Completion Date: June 2014
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: RAD001 Drug: Everolimus
10 mg everolimus
Other Name: RAD001

Detailed Description:

Cholangiocarcinoma is one of the most common cause of cancer death in Thailand. Patients with cholangiocarcinoma are often diagnosed at advanced stage. Palliative therapeutic approaches consisting of percutaneous and endoscopic biliary drainage have usually been used for these patients, since there is no effective chemotherapeutic treatment for this type of cancer. Activation of the phosphoinositide-3-kinase (PI3K)/Akt/mTOR signaling pathway is frequently found in cholangiocarcinoma cells. It has been suggested to be a key step leading to the progression of cholangiocarcinoma. In this study, the investigators hypothesize that inhibition of mTOR may be useful in treating cholangiocarcinoma.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Histologic confirmed diagnosis of cholangiocarcinoma.
  • Patients must present with disease not amenable to curative surgery.
  • ECOG performance status of < 2
  • Patients with at least one measurable lesion at baseline as per the RECIST criteria.
  • The following laboratory parameters at screening (visit 1):

WBC are equal to or more than 3,000/uL. Platelet are equal to or more than 100,000/uL Alanine transaminase (ALT) and aspartate transaminase (AST) ≤ 2.5 x ULN. Patients with known liver metastases: AST and ALT ≤ 5 x ULN Total Bilirubin < 2 mg/dl* (after drainage) Serum creatinine equal to or less than 2.0 x upper normal limit

  • Life expectancy equal to or more than 12 weeks.
  • Ability to understand and willingness to sign a written informed consent and to be able to follow the visit schedule.
  • Female patients at child-bearing age must have negative pregnancy test.
  • Patients refuse to have treatment with Chemotherapy or Radiation.

Exclusion Criteria:

  • Patients within 2 weeks post-minor surgery, 4 weeks post-major surgery to avoid wound healing complications. Percutaneous biopsies require no waiting time prior to study entry.
  • Patients with a recent history of hemoptysis, ≥ 0.5 teaspoon of red blood.
  • Patients who have received prior systemic treatment for their metastatic cholangiocarcinoma.
  • Presence of clinically relevant ascites or liver failure.
  • Patients with extensive symptomatic fibrosis of the lungs.
  • Patients with a known hypersensitivity to RAD001 (everolimus).
  • Patients who have previously received mTOR inhibitors (sirolimus, temsirolimus, everolimus, deforolimus).
  • History or clinical evidence of central nervous system (CNS) metastases. Note: Subjects who have previously-treated CNS metastases (surgery±radiotherapy, radiosurgery, or gamma knife) and meet all 3 of the following criteria are eligible:

Are asymptomatic Have had no evidence of active CNS metastases for ≥ 6 months prior to enrollment and Have no requirement for steroids or enzyme-inducing anticonvulsants (EIAC)

  • Clinically significant gastrointestinal abnormalities including, but not limited to:

Malabsorption syndrome Major resection of the stomach or small bowel that could affect the absorption of RAD001 Active peptic ulcer disease Inflammatory bowel disease Ulcerative colitis, or other gastrointestinal conditions with increased risk of perforation History of abdominal fistula, gastrointestinal perforation, or intra abdominal abscess within 28 days prior to beginning of study treatment;

  • Patients receiving chronic systemic treatment with corticosteroids or another immunosuppressive agent. Inhaled and topical steroids are acceptable
  • Patients with a known history of human immunodeficiency virus seropositivity
  • Patients with autoimmune hepatitis
  • Patients with an active, bleeding diathesis. Patients may use coumadin or heparin preparations.
  • Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study.
  • Patients who have a history of another primary malignancy ≤ 3 years, with the exception of non-melanoma skin cancer and carcinoma in situ of uterine.
  • Female patients who are pregnant or breastfeeding, or adults of reproductive potential who are not using effective birth control methods.
  • Patients who are using other investigational agents or who had received investigational drugs ≤ 4 weeks prior to study treatment start.
  • Patients unwilling or unable to comply with the protocol.
  • Patient who will have got benefit from Radiation or Chemotherapy.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01525719

Sponsors and Collaborators
Ratchavithi Hospital
Investigators
Principal Investigator: Kawin Leelawat, MD, PhD Rajavithi Hospital
  More Information

No publications provided

Responsible Party: Kawin Leelawat, Department of Surgery, Ratchavithi Hospital
ClinicalTrials.gov Identifier: NCT01525719     History of Changes
Other Study ID Numbers: R-53326
Study First Received: January 31, 2012
Last Updated: February 2, 2012
Health Authority: Thailand: Ministry of Public Health

Keywords provided by Ratchavithi Hospital:
cholangiocarcinoma
RAD001
everolimus

Additional relevant MeSH terms:
Cholangiocarcinoma
Adenocarcinoma
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Everolimus
Sirolimus
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Pharmacologic Actions
Antibiotics, Antineoplastic
Antineoplastic Agents
Therapeutic Uses
Antifungal Agents
Anti-Infective Agents
Anti-Bacterial Agents

ClinicalTrials.gov processed this record on July 28, 2014