Carbon Monoxide Therapy for Severe Pulmonary Arterial Hypertension (CO in PAH)

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified January 2012 by University of Illinois at Chicago
Sponsor:
Collaborators:
Information provided by (Responsible Party):
Roberto Machado, M.D., University of Illinois
ClinicalTrials.gov Identifier:
NCT01523548
First received: January 27, 2012
Last updated: January 31, 2012
Last verified: January 2012
  Purpose

The purpose of this study is to examine the potential of carbon monoxide (CO) to decrease elevated blood pressure in the pulmonary artery. This symptom is seen in patients with pulmonary arterial hypertension, a rare disease that causes fatigue, dizziness, and shortness of breath because the blood vessels that supply the lungs narrow, forcing the heart to work harder to push blood through. Previous studies in the laboratory have shown that carbon monoxide has promise in treating these symptoms.

Subjects in this study are being asked to undergo a new type of treatment to improve pulmonary arterial hypertension by breathing CO gas. CO is a colorless, tasteless, odorless gas usually found in car exhaust or cigarette smoke. It is administered with a continuous flow of air. Subjects will undergo a screening process during which it will be determined if they are eligible for the study. After the screening process, if subjects meet eligibility criteria for the study, they will begin carbon monoxide treatment through a cushioned mask that is placed over the nose and mouth. This treatment will last for sixteen weeks.


Condition Intervention Phase
Hypertension, Pulmonary
Drug: Carbon Monoxide
Phase 1
Phase 2

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Carbon Monoxide Therapy for Severe Pulmonary Arterial Hypertension

Resource links provided by NLM:


Further study details as provided by University of Illinois at Chicago:

Primary Outcome Measures:
  • Evidence of a 20% decrease in pulmonary vascular resistance post-therapy when compared to pre-therapy value [ Time Frame: At baseline and after 16 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Effect of 16-weeks CO inhalation on other pulmonary and systemic hemodynamic parameters [ Time Frame: 16 weeks ] [ Designated as safety issue: No ]
  • Effect of 16-weeks CO inhalation on functional capacity assessed by six-minute walk test [ Time Frame: 16 weeks ] [ Designated as safety issue: No ]
  • Effect of 16-weeks CO inhalation on Brain Natriuretic Peptide levels [ Time Frame: 16 weeks ] [ Designated as safety issue: No ]
  • Effect of 16-weeks CO inhalation on right ventricular echocardiographic parameters [ Time Frame: 16 weeks ] [ Designated as safety issue: No ]
  • Effect of 16-weeks CO inhalation on acute pulmonary vasoreactivity [ Time Frame: 16 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 20
Study Start Date: July 2012
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Carbon Monoxide
Inhaled Carbon Monoxide therapy administered over 16 weeks
Drug: Carbon Monoxide
150 ppm x 3 hours once weekly (week 1) 150 ppm x 3 hours twice weekly (week 2) 150 ppm x 3 hours three times a week (week 3-16)

Detailed Description:

Pulmonary arterial hypertension (PAH) remains an uncommon debilitating and fatal disease, and is clinically marked by a progressive increase in pulmonary vascular resistance leading to right heart failure and ultimately death. Currently the treatment options available for those suffering from PAH target cellular dysfunction that leads to constriction of the vasculature. Although there is some evidence that available therapies have secondary effects on vascular remodeling there are currently no therapies that target abnormal cell proliferation in PAH.

Carbon monoxide (CO) is a gaseous molecule with known toxicity and lethality to living organisms when exposed to high concentrations for sustained periods. However, CO has shown promise in preclinical models of pulmonary hypertension. Recent studies have shown that mammalian cells have the ability to generate endogenous CO primarily through the catalysis of heme by the heme oxygenase enzymatic system and there is ample evidence demonstrating that CO behaves as a signaling molecule in cellular and biological processes. Furthermore, CO has been demonstrated to exert key physiological and protective functions in various models of tissue inflammation and injury.

This study will evaluate the safety and potential efficacy of inhaled CO in subjects with severe PAH. Over forty subjects with severe PAH despite best available therapy will be screened from the UIC pulmonary vascular disease clinic, of which twenty subjects will be recruited for participation in the trial. The trial will consist of an initial screening period to determine subjects' eligibility for the study. This will be based on a previous echocardiogram, a six minute walk test and right heart catheterization done as part of standard care for subjects with pulmonary arterial hypertension. Following the initial screening, the trial will last sixteen weeks, during which subjects will receive inhaled carbon monoxide up to three times weekly at the University of Illinois at Chicago.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • male and female ≥ 18 years old , with Pulmonary Arterial Hypertension
  • Right heart catheterization diagnosis of PAH:

    • Mean Pulmonary Artery Pressure (mPAP)> 25 mmHg at rest
    • Pulmonary Capillary Occlusion Pressure (PCOP) or Left Ventricular End Diastolic Pressure (LVEDP) < 15 mmHg
    • Pulmonary Vascular Resistance (PVR) > 3 mmHg/L/min
  • Must be Class 1.1, 1.2, or 1.3 PAH (see Appendix A)
  • Echocardiographic evidence of Right Ventricular Dysfunction
  • On standard and stable PAH therapy (no dose changes in the 4 weeks prior to starting the study medication) including:

    • A Prostacyclin (IV epoprostenol, IV or subcutaneous remodulin, inhaled iloprost or remodulin) unless willing or unable to tolerate therapy AND
    • Phosphodiesterase type 5 inhibitor OR
    • Endothelin Receptor Antagonist OR
    • Any combination of a-c
  • NYHA class III or IV despite 3 months of stable therapy as outlined above
  • 6 minute walk distance ≤ 380m
  • Negative serum pregnancy test
  • Female of childbearing age either surgically sterilized or using acceptable method of contraception. Acceptable methods of contraception include oral contraceptives, IUD, or other barrier methods of contraception.

Exclusion Criteria:

  • History of malignancy in 2 years prior to enrollment
  • Baseline cytopenia's:

    • White blood cell count ≤ 3,000 i. Absolute Neutrophil Count (ANC) less than 1500 cells/mm3
    • Hemoglobin ≤ 7
    • Platelet ≤ 100,000
  • Baseline Liver Disease:

    • ALT/AST, ALk phos > 2.5x ULN, INR > 1.5
    • Bilirubin > 1.5 x ULN
  • Coronary artery disease
  • Any cause of pulmonary hypertension other than class 1.1, 1.2, or 1.3 PAH.
  • Baseline Renal Disease: Cr ≥ 2
  • Active Smoker
  • Hypoxemia with SaO2 < 95% on oxygen 2 L/min
  • Baseline COHb > 2%
  • Pregnancy or lactation
  • Inability to attend scheduled clinic visits
  • Previous lung transplant
  • Naive to available standard PAH therapy
  • Pulmonary Capillary Occlusion Pressure (PCOP) or LEft Ventricular End Diastolic Pressure (LVEDP)< 15 mmHg
  • Concomitant enrollment in another investigational treatment protocol for PAH or taking any off label drug therapy for PAH
  • Recent enrollment in or plans to enroll in Pulmonary Rehabilitation during the study period
  • Any condition that in the opinion of the investigator would prevent completion of study procedures
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01523548

Contacts
Contact: Roberto F Machado, MD (312) 355-5894 machador@uic.edu

Locations
United States, Illinois
University of Illinois at Chicago Medical Center Not yet recruiting
Chicago, Illinois, United States, 60612
Contact: Colleen M Huml    312-355-1470    chuml2@uic.edu   
Principal Investigator: Roberto F Machado, MD         
Sponsors and Collaborators
University of Illinois at Chicago
Investigators
Principal Investigator: Roberto F Machado, MD University of Illinois at Chicago
  More Information

No publications provided

Responsible Party: Roberto Machado, M.D., Associate Professor of Pulmonary Medicine, University of Illinois
ClinicalTrials.gov Identifier: NCT01523548     History of Changes
Other Study ID Numbers: 2010-06425, K23HL098454
Study First Received: January 27, 2012
Last Updated: January 31, 2012
Health Authority: United States: Food and Drug Administration

Keywords provided by University of Illinois at Chicago:
Carbon Monoxide
Hypertension, Pulmonary

Additional relevant MeSH terms:
Hypertension, Pulmonary
Hypertension
Lung Diseases
Respiratory Tract Diseases
Vascular Diseases
Cardiovascular Diseases
Carbon Monoxide
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Gasotransmitters
Neurotransmitter Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on August 28, 2014