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Cognitive Training for Patients With Schizophrenia

This study has been completed.
Sponsor:
Collaborator:
National Alliance for Research on Schizophrenia and Depression
Information provided by (Responsible Party):
Elizabeth Twamley, University of California, San Diego
ClinicalTrials.gov Identifier:
NCT01521026
First received: January 22, 2012
Last updated: January 25, 2012
Last verified: January 2012
History of Changes
  Purpose

This research on cognitive training addresses the following questions:

  1. Does cognitive training lead to improved cognition, functional abilities, psychiatric symptoms, treatment adherence, or quality of life in patients with psychoses?
  2. What are the neurocognitive and non-cognitive factors that predict good outcomes following cognitive rehabilitation? In addition to verbal learning and memory, immediate verbal memory, vigilance, and executive functioning, the cognitive training intervention attempted to improve prospective memory ability (i.e., the ability to remember to do things in the future, such as take medications or attend a doctor's appointment).

Condition Intervention Phase
Schizophrenia
Schizoaffective Disorder
Other Primary Psychotic Disorders
 Behavioral: Cognitive Training
 Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Cognitive Training for Patients With Schizophrenia

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Institute of Mental Health (NIMH):

Primary Outcome Measures:
  • UCSD Performance-based Skills Assessment Total Score [ Time Frame: 3 months ] [ Designated as safety issue: No ]
    Performance-based measure of functional capacity in five domains: Communication, Finance, Recreation Planning, Transportation, and Household Chores


Secondary Outcome Measures:
  • Cognitive performance [ Time Frame: 0, 3, 6 months ] [ Designated as safety issue: No ]

Enrollment: 69
Study Start Date: September 2003
Study Completion Date: August 2009
Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cognitive Training
Cognitive training group
 Behavioral: Cognitive Training
12-week compensatory cognitive training in group format
No Intervention: Standard Pharmacotherapy

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Primary psychotic disorder (including schizophrenia, schizoaffective disorder, psychotic mood disorder, or psychosis NOS)
  • Age 18 or older
  • Fluency in English

Exclusion Criteria:

  • Dementia
  • Neurological conditions affecting cognition
  • Mental retardation
  • Substance use disorder within the past month
  • Participation in other intervention trials
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01521026

Locations
United States, California
UCSD Outpatient Psychiatric Services
San Diego, California, United States, 92103
Sponsors and Collaborators
National Institute of Mental Health (NIMH)
National Alliance for Research on Schizophrenia and Depression
Investigators
Principal Investigator: Elizabeth W Twamley, PhD UCSD
  More Information

No publications provided by National Institute of Mental Health (NIMH)

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Elizabeth Twamley, Associate Professor of Psychiatry, University of California, San Diego
ClinicalTrials.gov Identifier: NCT01521026     History of Changes
Other Study ID Numbers: NARSAD Young Investigator
Study First Received: January 22, 2012
Last Updated: January 25, 2012
Health Authority: United States: Institutional Review Board
United States: Federal Government

Additional relevant MeSH terms:
Psychotic Disorders
Mental Disorders
Schizophrenia
Schizophrenia and Disorders with Psychotic Features

ClinicalTrials.gov processed this record on May 16, 2013