Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. (MMI)
The structural/RSN study involves Structural and Resting State Neuroimaging. The purpose of Structural Neuroimaging is to use MRI technology to identify cortical and white matter morphometric differences between patients with chronic pain conditions (in this study: IBS) and healthy control subjects.
The purpose of the Resting State Neuroimaging study is to use functional MRI to identify possible disease related differences in various resting state networks in the brain.
The overall goal is to identify structural and functional brain abnormalities in patients with chronic pain conditions, such as Irritable Bowel Syndrome (IBS), Functional Dyspepsia (FD), Cyclical Vomiting Syndrome (CVs), Non Cardiac Chest Pain (NCCP) or Inflammatory Bowel Disease (IBD), and comparing those differences between conditions; and matched healthy control subjects.
Irritable Bowel Syndrome
Non Cardiac Chest Pain
Cyclical Vomiting Syndrome
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||A Magnetic Resonance Imaging (MRI) Study to Investigate Differences in the Structure and the Function of the Brain at Rest; Between Persons With Functional Pain Conditions or IBD and Healthy Controls|
- Resting state networks [ Time Frame: within 1 week of scanning visit ] [ Designated as safety issue: No ]The resting state functional MRI scan will be done to assess differences in the resting state networks in subjects with chronic pain conditions in comparison to healthy controls.
|Study Start Date:||March 2011|
|Estimated Study Completion Date:||August 2013|
|Estimated Primary Completion Date:||August 2013 (Final data collection date for primary outcome measure)|
Functional Pain Conditions and Inflammatory bowel disease
Cyclical Vomiting Syndrome, Irritable Bowel Syndrome, Non-Cardiac Chest Pain, Functional Dyspepsia, Inflammatory Bowel disease, vulvodynia
Inflammatory Bowel Disease
Subjects diagnosed with Crohn's Disease or Ulcerative Colitis.
The study involves 2 visits. The screening visit is about 90 minutes and involves signing the consent, completing questionnaires, a medical history and modified physical exam and psychological interview to identify stressors, anxiety, depression and other conditions.
The second visit is the MRI visit (both functional and structural) and also will take about 90 minutes, with the scanning lasting about 45 minutes. There are questionnaires and a measure of skin conductance also.
|Contact: Jean Stains, BSN, RNfirstname.lastname@example.org|
|Contact: Nuwanthi Heendeniya, B.Sc.||email@example.com|
|United States, California|
|Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress||Recruiting|
|Los Angeles, California, United States, 90095|
|Contact: Jean Stains, RN 310-206-1758 firstname.lastname@example.org|
|Contact: Nuwanthi Heendeniya, BSc 310-206-8545 email@example.com|
|Principal Investigator: Emeran Mayer, MD|
|Principal Investigator:||Emeran Mayer, MD||University of California, Los Angeles|