PRE-Symptomatic Studies in ALS (PRESS-ALS)

This study is currently recruiting participants.
Verified December 2013 by University of Miami
Information provided by (Responsible Party):
Michael Benatar, University of Miami Identifier:
First received: January 9, 2012
Last updated: December 2, 2013
Last verified: December 2013

The goal of PRESS-ALS is to study the earliest manifestations of disease in people with early ALS in whom some areas of the body are not yet affected.

Amyotrophic Lateral Sclerosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by University of Miami:

Primary Outcome Measures:
  • Phenoconversion [ Time Frame: Every three months over the course of one year ] [ Designated as safety issue: No ]

Estimated Enrollment: 100
Study Start Date: November 2013
Estimated Primary Completion Date: December 2018 (Final data collection date for primary outcome measure)
Healthy individuals (controls)
Individuals affected with ALS (sporadic or familial)


Ages Eligible for Study:   18 Years to 95 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

People affected with ALS (either familial or sporadic) and healthy controls


For individuals with ALS: At least one region (e.g. arm, leg, bulbar) must still be clinically unaffected.

For healthy controls: No family history of ALS or a related disorder

  Contacts and Locations
Please refer to this study by its identifier: NCT01508962

United States, Florida
University of Miami Recruiting
Miami, Florida, United States, 33136
Contact: Michael Benatar, MD, PhD    305-243-6480   
Contact: Sara-Claude Michon, PhD (coordinator)    305-243-6481   
Sponsors and Collaborators
University of Miami
  More Information

Additional Information:
No publications provided

Responsible Party: Michael Benatar, Associate Professor of Neurology, University of Miami Identifier: NCT01508962     History of Changes
Other Study ID Numbers: PRESS-ALS
Study First Received: January 9, 2012
Last Updated: December 2, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Miami:
Disease onset
Disease progression

Additional relevant MeSH terms:
Amyotrophic Lateral Sclerosis
Motor Neuron Disease
Spinal Cord Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
TDP-43 Proteinopathies
Neuromuscular Diseases
Proteostasis Deficiencies
Metabolic Diseases
Pathologic Processes processed this record on April 17, 2014