ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators
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Purpose
The investigators propose a test of causality by examining a cohort of patients undergoing deep brain stimulation (DBS) within the ventral striatum. The investigators will examine behavior on and off stimulation across a range of tasks that index different forms of impulsivity. Patients will be studied in both the ON and OFF state - that is, they will be tested during active deep brain stimulation and 30 min to 1 hour after stimulation has been stopped (order of state will be counterbalanced across subjects). The investigators specific aim is to test the hypothesis that enhancing ventral striatal signaling (i.e. ON-state DBS) will cause more impulsive patterns of behavior across several impulsivity tasks. The investigators predict that ventral striatal DBS will increase stop-signal reaction time on the stop-signal task and commission errors on the Go/NoGo task, and increase delay aversion in a delay discounting paradigm.
| Condition |
|---|
|
Obesessive Compulsive Disorder Major Depressive Disorder |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Cross-Sectional |
| Official Title: | ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators |
- Impulsive Action [ Time Frame: 2 hours ] [ Designated as safety issue: No ]As measured by the Go/No Go task
- Impulsive Choice [ Time Frame: 2 hours ] [ Designated as safety issue: No ]As measured by delayed discounting task
| Estimated Enrollment: | 30 |
| Study Start Date: | February 2012 |
| Estimated Study Completion Date: | December 2014 |
| Estimated Primary Completion Date: | December 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
| Patients with Deep Brain Stimulators |
Show Detailed Description Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patients with Deep Brain Stimulators
Inclusion Criteria:
- Deep brain stimulator implantation performed at least three months prior to study
Exclusion Criteria:
- Subjects unable to visualize stimulus objects with correction
- Dementia or other known cognitive deficit
Contacts and Locations| Contact: Alexandra M Rodman, BA | 617-726-9281 | arodman@partners.org |
| United States, Massachusetts | |
| Massachusetts General Hospital | Recruiting |
| Boston, Massachusetts, United States, 02114 | |
| Contact: Darin D Dougherty, MD ddougherty@partners.org | |
| Massachusetts General Hospital | Not yet recruiting |
| Charlestown, Massachusetts, United States, 02129 | |
| Principal Investigator: | Darin D Dougherty, MD | Massachusetts General Hospital |
More Information
No publications provided
| Responsible Party: | Darin Dougherty, Associate Professor of Psychiatry, Massachusetts General Hospital |
| ClinicalTrials.gov Identifier: | NCT01506206 History of Changes |
| Other Study ID Numbers: | 2011P002546 |
| Study First Received: | January 5, 2012 |
| Last Updated: | April 22, 2013 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Massachusetts General Hospital:
|
Deep Brain Stimulation Impulsivity |
Additional relevant MeSH terms:
|
Depressive Disorder Depression Impulsive Behavior Depressive Disorder, Major Compulsive Personality Disorder |
Mood Disorders Mental Disorders Behavioral Symptoms Personality Disorders |
ClinicalTrials.gov processed this record on June 18, 2013