Caris Biorepository Research Protocol

• Develop biorepository that ensures molecular integrity and clinical relevance of quality human biospecimens and associated clinical data. [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  Retention of biospecimen samples with DNA
  
  
• Implement release of specimens from biorepository for testing [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  Research for the purposes of cancer laboratory diagnostic tests.
  
  

• Laboratory testing [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  DNA and RNA microarray
  
  
• Laboratory testing [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  Immunohistochemistry
  
  
• Laboratory testing [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  Gene and protein expression, proteomics and matabolomics
  
  
• Laboratory testing [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  Mutation analysis
  
  
• Laboratory testing [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  Experiemental lab testing for development of new diagnostic technology
  
  
• Laboratory testing [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  Microvesicle discovery, characterization and validation.
  
  

The Caris Biorepository is an effort toward defining the future of medicine incorporating the discoveries of the genomic era by providing physicians, researchers and scientists access to quality human specimens and data aimed at improving human health and fighting disease. This will be accomplished through acquiring and sharing valuable biospecimen information and clinical outcomes in a collaborative, secure environment. The Caris Biorepository will bridge the gap and correlate human specimens with clinical and specimen data valuable to multiple and varying entities interested in advancing science with precision medicine by targeting disease treatments.

The objective of this project is to develop and implement a state-of-the-science Biorepository that ensures molecular integrity and clinical relevance of human biospecimens used in research and clinical medicine. The Caris Biorepository will also provide vital biospecimens and data to internal researchers and external research collaborators such as government, academia and industry collaborators for the use of drug development discoveries, clinically relevant research trials, publications and posters, and the implementation of future healthcare policies. This project may also impact characterization of trends in practice patterns and their relation to patient outcomes as well as the economic implications of differing evaluation, treatment and management paradigms.