Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma
This study is ongoing, but not recruiting participants.
Sponsor:
Children's Oncology Group
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01493830
First received: December 15, 2011
Last updated: December 22, 2011
Last verified: December 2011
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Purpose
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies biomarkers in tumor samples from younger patients with neuroblastoma.
| Condition | Intervention |
|---|---|
|
Neuroblastoma |
Genetic: fluorescence in situ hybridization Genetic: gene expression analysis Genetic: microarray analysis Genetic: mutation analysis Genetic: protein analysis Other: immunohistochemistry staining method Other: laboratory biomarker analysis Other: microscopy |
| Study Type: | Observational |
| Official Title: | Proposed Studies on the Role of Growth Factor Receptor Trafficking in Neuroblastoma Pathogenesis |
Resource links provided by NLM:
Further study details as provided by National Cancer Institute (NCI):
Primary Outcome Measures:
- Expression of UBE4B, hrs, and members of the ubiquitination protein complex [ Designated as safety issue: No ]
- Expression levels and cellular localization of the UBE4B, hrs, and growth factor receptors [ Designated as safety issue: No ]
- 1p36 deletion status and its association with UBE4B [ Designated as safety issue: No ]
| Estimated Enrollment: | 5 |
| Study Start Date: | December 2011 |
| Estimated Primary Completion Date: | February 2012 (Final data collection date for primary outcome measure) |
OBJECTIVES:
- To determine the expression of UBE4B, hrs, and members of the ubiquitination protein complex in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group.
- To determine the correlation of expression levels and cellular localization of the UBE4B and hrs proteins with growth factor-receptor tumor cell-surface expression.
- To determine the 1p36 deletion status by fluorescence in situ hybridization (FISH) analysis and their association with expression levels of UBE4B and hrs in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group.
OUTLINE: Banked tumor tissue samples are analyzed for expression of UBE4B, hrs, members of the ubiquitination protein complex, growth factor receptors, and 1p36 deletion status by immunohistochemistry (IHC), fluorescent microscopy, and fluorescence in situ hybridization (FISH).
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
DISEASE CHARACTERISTICS:
- Tumor tissue microarrays from the Children's Oncology Group neuroblastoma tumor bank
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Contacts and Locations More Information
Additional Information:
No publications provided
| Responsible Party: | Peter C. Adamson, Children's Oncology Group - Group Chair Office |
| ClinicalTrials.gov Identifier: | NCT01493830 History of Changes |
| Other Study ID Numbers: | CDR0000719951, COG-ANBL12B4 |
| Study First Received: | December 15, 2011 |
| Last Updated: | December 22, 2011 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Cancer Institute (NCI):
|
neuroblastoma |
Additional relevant MeSH terms:
|
Neuroblastoma Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumors, Primitive Neoplasms, Neuroepithelial Neuroectodermal Tumors |
Neoplasms, Germ Cell and Embryonal Neoplasms by Histologic Type Neoplasms Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue |
ClinicalTrials.gov processed this record on May 23, 2013