Functional Imaging of Psychic Pain

• Cerebral regions associated with psychic pain during a major depressive disorder [ Time Frame: One day ] [ Designated as safety issue: No ]
  Magnetic Resonance Imaging to visualize cerebral regions associated with psychic pain during a major depressive disorder
  
  
• Cerebral regions associated with perception of social exclusion [ Time Frame: One day ] [ Designated as safety issue: No ]
  Magnetic Resonance Imaging to visualize the cerebral regions associated with perception of social exclusion
  
  

Behavioral: Assessment of personality traits
suicide behaviour , psychic pain, social exclusion, decision making...
Other Names:
• impulsivity
• anger
• anxiety
• emotional lability
• self-administered questionnaires
Behavioral: Assessment of suicidal act
suicide behaviour , psychic pain, social exclusion, decision making...
Other Names:
• SIS
• RRRS
Behavioral: Assessment of depression
suicide behaviour , psychic pain, social exclusion, decision making...
Other Names:
• BDI
• HAMD-21
Procedure: Cyber ball game
functional neuroimaging
Other Name: fIRM
Procedure: Iowa Gambling Task
functional neuroimaging
Other Name: Iowa Gambling Task
Procedure: Microcomputer
functional neuroimaging
Other Name: palm
Procedure: blood sample
blood sample
Other Name: blood sample

Suicide behaviour (SB) represents a major public health problem. In order to improve prevention strategies, a better understanding of the physiopathology of SB is needed. According to a "stress vulnerability" model, people who make a suicide attempt when they are subject to a stress factor (environmental stress, interpersonal difficulties, depression, tobacco, substance abuse...) are those who have a specific vulnerability. Vulnerability factors to SB may be considered in clinical terms (propensity to hopelessness, aggressive impulsivity traits), neurobiological terms (serotoninergic system disorder, especially in the ventral prefrontal cortex-vPFC) and cognitive terms (decision making, cognitive functions mediated by the vPFC and the serotoninergic system). Finally, genetic factors seem also involved in suicide vulnerability. The investigators have conducted a preliminary study which suggests that increased perception of psychic pain during a major depressive disorder increases suicidal ideation and suicidal act. Study about anatomic basis of psychic pain and its triggers represents a relevant theme to understand the suicidal process. Among the classical factors triggering psychic pain and suicidal act, events of social exclusion appears to be crucial. Finally, many data suggests the close relationship between physic and psychic pain.