Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation
The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation. Furthermore, since there exist no current information on the key Ca2+-handling proteins RyR, NCX, and SERCA-2a from patients in Atrial Fibrillation (AF) the investigators sought to determine whether a regulation of these proteins may be an underlying cause of the disease. Mitochondrial function will also studied.
- The investigators hypothesize that structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared to patients in sinus rhythm.
- The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared to patients in sinus rhythm.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Ultrastructure of Sarcolemma, Immunofluorescence of Calcium Handling Proteins and Mitochondrial Function in Atrial Myocytes of Patients in Sinus Rhythm and With Atrial Fibrillation|
Myocardial tissue from the right and left atrial appendage.
|Study Start Date:||April 2010|
|Estimated Study Completion Date:||February 2012|
|Estimated Primary Completion Date:||February 2012 (Final data collection date for primary outcome measure)|
|stable sinus rhythm|
|permanent atrial fibrillation|
|paroxysmal atrial fibrillation|