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Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
K. Sreekumaran Nair, Mayo Clinic
ClinicalTrials.gov Identifier:
NCT01489930
First received: November 18, 2011
Last updated: December 9, 2011
Last verified: December 2011
History of Changes
  Purpose

Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training.

Hypotheses.

  1. to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program
  2. to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age
  3. to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program
  4. to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age

Condition Intervention
Sarcopenia
 Behavioral: Endurance exercise
Behavioral: Resistance exercise
Behavioral: Control/Combined training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Mayo Clinic:

Primary Outcome Measures:
  • Skeletal Muscle Protein Synthesis [ Time Frame: Measured at week 0 (baseline) and week 8 ] [ Designated as safety issue: No ]
    The investigators will determine the change from baseline in skeletal muscle protein synthesis. Measurments will be performed at baseline and following 8 weeks of exercise training.


Secondary Outcome Measures:
  • Mitochondrial Function [ Time Frame: Measured at week 0 (baseline) and week 8 ] [ Designated as safety issue: No ]
    The investigators will determine the change from baseline in mitochondrial function. Measurments will be performed at baseline and following 8 weeks of exercise training.


Enrollment: 67
Study Start Date: May 2008
Study Completion Date: February 2011
Primary Completion Date: February 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Endurance Exercise
Participants will perform 8-weeks of moderate intensity endurance (cycling) exercise
 Behavioral: Endurance exercise
Participants will perform 8-weeks of endurance exercise training. Participants will train 5 days per week for 60 min at 65% of VO2 peak.
Experimental: Resistance Exercise
Participants will perform 8-weeks of whole-body resistance exercise training.
 Behavioral: Resistance exercise
Participants will perform 8-weeks of resistance exercise training. Participants will train 4 days per week for ~60 min. Two days will focus on lower body resistance training and two days will focus on upper body.
Experimental: Control / Combined Training
Participants will perform 8-weeks of no exercise, followed by an additional 8-weeks of combined endurance plus resistance exercise training.
 Behavioral: Control/Combined training
Participants will perform 8-weeks of no exercise (control), followed by 8-weeks of combined endurance and resistance training. Participants will endurance train 5 days per week for 30 min at 65% of VO2 peak and resistance train 4 days per week for 30 min.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • 18 to 30 or >65 years
  • Males and Females

Exclusion Criteria:

  • Regular Exercise Program
  • Smoking
  • Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders)
  • Drugs known to impair metabolic function (beta blockers, steroids)
  • Allergies to lidocaine
  • Physical disability that precludes exercise
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01489930

Locations
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Investigators
Principal Investigator: K. Sreekumaran Nair, MD, PD Mayo Clinic
  More Information

No publications provided

Responsible Party: K. Sreekumaran Nair, Professor of Medicine, Mayo Clinic
ClinicalTrials.gov Identifier: NCT01489930     History of Changes
Other Study ID Numbers: 07-007689
Study First Received: November 18, 2011
Last Updated: December 9, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by Mayo Clinic:
Exercise
Aging
Sarcopenia
Mitochondria

Additional relevant MeSH terms:
Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
 Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms

ClinicalTrials.gov processed this record on May 16, 2013