ABT-888 With Modified FOLFOX6 in Patients With Metastatic Pancreatic Cancer

Inclusion Criteria:

• Histologically proven pancreatic adenocarcinoma with measurable disease
• ECOG performance status 0-2
• Subjects with no brain metastases or a history of previously treated brain metastases who have been treated with surgery or stereotactic radiosurgery at least 4 weeks prior to enrollment and have a baseline MRI that shows no evidence of intercranial disease and have not had treatment with steroids within 1 week of study enrollment.
• Subjects may have received any number of prior therapies except prior therapy with a PARP inhibitor
• At least 14 days must have passed since all prior anti-cancer therapy
• At least 28 days must have passed since any prior antibody-based therapies
• At least 28 days must have passed since any prior investigational agent
• All patients must have completely recovered from all transient side effects related to prior therapies and any side effects that are expected to be more durable or permanent must have resolved to Grade 1
• Adequate hepatic, bone marrow and renal function
• Partial thromboplastin time must be </= 2 X upper limit of institution's normal range and INR < 2. Subjects on an anticoagulant must have a PTT </= 5 X upper limit of institution's normal range and INR < 5.
• Life expectancy > 12 weeks
• Women of childbearing potential must have a negative serum pregnancy test within 14 days prior to initiation of treatment
• Subject must be capable of understanding and complying with parameters as outlined in protocol and able to sign and date the informed consent form
• Patients must have fully recovered from all effects of surgery.

Exclusion Criteria:

• Active severe infection, or known chronic infection with HIV, Hepatitis B virus or Hepatitis C virus
• Cardiovascular disease problems including unstable angina, therapy for life-threatening ventricular arrhythmia, or myocardial infarction, stroke, or congestive heart failure within the last 6 months
• Life-threatening visceral disease or other severe concurrent disease
• Women who are pregnant or breast-feeding
• Anticipated survival under 3 months
• The subject has had another active malignancy within the past 5 years except for cervical cancer in situ, in situ carcinoma of the bladder, or non-melanoma carcinoma of the skin.
• Active uncontrolled infection
• Symptomatic congestive heart failure
• Unstable angina pectoris or cardiac arrhythmia
• Psychiatric illness/ social situation that would limit compliance with study requirements