Prevalence of Congenital Uterine Malformations (PUMA)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
Aims: We plan to investigate how common uterine malformations are in high-risk women (with history of miscarriage or preterm delivery), by analysing different characteristics in these groups. This study will also investigate other ultrasound characteristics detected on these women. This study will point towards the possible mechanism of how uterine malformations may affect pregnancy outcomes.
| Condition |
|---|
|
Congenital Uterine Anomalies |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Prevalence of Congenital Uterine Malformations in Women With a History of Preterm Delivery or Miscarriage |
- Presence of uterine malformations [ Time Frame: At least 8 weeks after the end of last pregnancy ] [ Designated as safety issue: No ]Presence of uterine malformations in study group compared to control group
- Ultrasound markers on pelvic 3D ultrasound [ Time Frame: At least 8 weeks after the end of last pregnancy ] [ Designated as safety issue: No ]Ultrasound markers on pelvic 3D ultrasound in study versus control group
| Estimated Enrollment: | 246 |
| Study Start Date: | September 2012 |
| Estimated Study Completion Date: | February 2014 |
| Estimated Primary Completion Date: | February 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Women with previous preterm birth
Women with history of preterm birth (birth of a baby of less than 37 weeks gestational age, where labour was spontaneous) regardless of past pregnancy history.
|
|
Women with previous miscarriage
Women with history of miscarriage (spontaneous pregnancy loss before 24 weeks of gestation), regardless of past pregnancy history.
|
|
Women with previous term births
Women with previous term births (37 or more weeks of gestation)
|
Detailed Description:
Background: Congenital abnormally shaped wombs (uterine malformations) have long been thought to be more common in women with poor pregnancy outcomes, e.g. miscarriage (Rackow and Arici 2007) and preterm delivery (Tomazevic, Ban-Frangez et al. 2007). However, the true prevalence is difficult to assess as there are no universally agreed classification systems and some of the best investigations are invasive. In addition, previous prevalence studies have not examined the details of subfertility or pregnancy loss, such as duration of subfertility, the gestation of pregnancy loss, or miscarriage pattern.
Aims: We plan to investigate how common uterine malformations are in high-risk women (with history of miscarriage or preterm delivery), by analysing different characteristics in these groups. This study will also investigate other ultrasound characteristics detected on these women. This study will point towards the possible mechanism of how uterine malformations may affect pregnancy outcomes.
Methods: We plan to recruit women who have had miscarriage or preterm delivery into our study. A sample of women who had normal term deliveries will be recruited as comparison. All women will undergo one 3-dimensional ultrasound scan each.
Outcomes: The proportions of women with congenital uterine malformations will be determined. Any ultrasound-detected markers found especially in women with poor pregnancy outcomes may point towards how uterine malformations affect pregnancies.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
Secondary care: Patients from Nottingham University Hospitals NHS Trust
Inclusion Criteria:
Women with a previous miscarriage
- Age: 18 years old or more
- Definition of miscarriage: the spontaneous pregnancy loss up until 24 weeks of gestation, where the pregnancy was confirmed histologically or with previous presence of a gestational sac with or without fetal pole and fetal heart activity on ultrasound scanning.
- At least 8 weeks after the end of last pregnancy
Women with preterm birth
- Age: 18 years old or more
- Definition of preterm birth: birth at less than 37 weeks of gestation.
- At least 8 weeks after the end of last pregnancy
Control group (women with term birth)
- Age: 18 years old or more
- Definition of term birth: birth at 37 or more weeks of gestation
- At least 8 weeks after the end of last pregnancy
Exclusion Criteria:
- Pregnant at the date of the 3D TVUS
- Recent uterine or endometrial surgery
- Women unable to tolerate 3D TVUS
- Unable to give informed consent
Contacts and Locations| Contact: Nicholas Raine-Fenning, MBChB PhD | +44(0)1158230700 | Nick.Raine-Fenning@nottingham.ac.uk |
| Contact: Yee Yin Chan, BMBS | mgxyyc@nottingham.ac.uk |
| United Kingdom | |
| Academic Imaging Suite, The University of Nottingham | Recruiting |
| Nottingham, Nottinghamshire, United Kingdom, NG7 2UH | |
| Principal Investigator: Nicholas Raine-Fenning, MBChB PhD | |
| Principal Investigator: | Nicholas Raine-Fenning, MBChB PhD | The University of Nottingham |
More Information
Publications:
| Responsible Party: | University of Nottingham |
| ClinicalTrials.gov Identifier: | NCT01487616 History of Changes |
| Other Study ID Numbers: | 11072 |
| Study First Received: | December 5, 2011 |
| Last Updated: | November 21, 2012 |
| Health Authority: | United Kingdom: Research Ethics Committee |
Keywords provided by University of Nottingham:
|
Mullerian anomalies Congenital uterine malformations or anomalies Arcuate Septate Subseptate |
Bicornuate Unicornuate Didelphys T-shaped |
Additional relevant MeSH terms:
|
Congenital Abnormalities |
ClinicalTrials.gov processed this record on June 18, 2013