Combined Electroencephalogram, Magnetic Resonance Imaging-Positron Emission Tomography of Dexmedetomidine Induced Sleep
The investigators are doing this research study to find out how and where dexmedetomidine, a sedative anesthetic , acts in the brain. The investigators will do this by using a machine that records the brains electrical activity, called an electroencephalogram (EEG), and brain imaging scans to look at the brain.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
|Official Title:||Combined Electroencephalogram, Magnetic Resonance Imaging-Positron Emission Tomography of Dexmedetomidine Induced Sleep|
- Combined Magnetic Resonance-Positron Emission Tomography Imagery of the brain under light sedation. [ Time Frame: 1.5hrs ] [ Designated as safety issue: No ]This study is intended to elicit the regions of the brain that are involved in dexmedetomidine induced sedation. This will be done with a functional imaging scan of the brain after with the imagery data will be processed and analyzed to help understand the regions of the brain implicated.
|Study Start Date:||September 2012|
|Study Completion Date:||July 2013|
|Primary Completion Date:||July 2013 (Final data collection date for primary outcome measure)|
Experimental: Active study arm
Subjects recruited into this study will be required to undergo two MR-PET scans of the brain in addition to high density EEG acquisition. The first scan will be a baseline scan while the second scan will be performed while dexmedetomidine is being infused.
The dexmedetomidine infusion will be individualized to each study participant by a target plasma concentration where LOC is initially observed. LOC will be assayed by specific auditory and verbal stimuli.
Other Name: precedex
Please refer to this study by its ClinicalTrials.gov identifier: NCT01485380
|United States, Massachusetts|
|Massachusetts General Hospital|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Oluwaseun Johson-Akeju, M.D||Massachusetts General Hospital|