Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients
The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of rheumatoid arthritis.
Disorders of Synovium, Multiple Sites
Disorders of Subchondral Bone, Multiple Sites
Disorders of Cartilage, Hand Joints
|Study Design:||Time Perspective: Cross-Sectional|
|Official Title:||Articular Sonography: Findings in Healthy Subjects Compared With Rheumatoid Arthritis Patients|
|Study Start Date:||March 2010|
|Study Completion Date:||June 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
normal, healthy people
rheumatoid arthritis patients
Rheumatoid arthritis (RA) is a chronic inflammatory, systemic and auto-imune disorder affecting primarily the joints. In RA, inflammatory synovium causes destruction of cartilage, erosion of the adjacent bone and ultimately loss of function of the affected joint. Newer imaging techniques, such as ultrasound (US), have shown promise in evaluation of RA. Many US scoring system have been used to classify and quantify the synovium, effusion, erosion and cartilage for assessing and monitoring AR. However, its use is considered problematical because there are very few data on normal joints and, at this point, there is no clear definition of excess amount of synovium in normal people.
|Study Chair:||Jamil Natour, professor||Federal University of São Paulo|
|Study Chair:||Rita NV Furtado, PhD||Federal University of São Paulo|
|Principal Investigator:||Flávia S Machado, master||Federal University of São Paulo|