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Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Antonio A.M. Castro, Federal University of São Paulo
ClinicalTrials.gov Identifier:
NCT01475812
First received: November 17, 2011
Last updated: November 18, 2011
Last verified: November 2011
  Purpose

Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).


Condition Intervention
Dynamic Lung Hyperinflation
COPD Patients
Activities of Daily Livin.
Other: Hyperinflation and ADL

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional

Resource links provided by NLM:


Further study details as provided by Federal University of São Paulo:

Primary Outcome Measures:
  • Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients. [ Time Frame: 3 months ] [ Designated as safety issue: No ]

Enrollment: 19
Study Start Date: March 2007
Groups/Cohorts Assigned Interventions
COPD hyperinflation Other: Hyperinflation and ADL
Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.

  Eligibility

Ages Eligible for Study:   50 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

The investigators included 19 COPD patients (13 male) with moderate to very severe degree of airway obstruction, with a mean post bronchodilator forced expiratory volume in the first second (FEV1) of 48.7 ± 7.1% predicted and mean age of 64.1 ± 5.3.

Criteria

Inclusion Criteria:

  • COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)
  • clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form

Exclusion Criteria:

  • Inability to perform the slow vital capacity maneuver
  • excessive perceived dyspnea during the test
  • arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01475812

Locations
Brazil
Federal University of São Paulo
São Paulo, São Paulo/SP, Brazil, 05414000
Sponsors and Collaborators
Federal University of São Paulo
  More Information

No publications provided

Responsible Party: Antonio A.M. Castro, Dr., Federal University of São Paulo
ClinicalTrials.gov Identifier: NCT01475812     History of Changes
Other Study ID Numbers: 0353/03
Study First Received: November 17, 2011
Last Updated: November 18, 2011
Health Authority: Brazil: National Committee of Ethics in Research

Keywords provided by Federal University of São Paulo:
COPD
activities of daily living
pulmonary hyperinflation
exercise

Additional relevant MeSH terms:
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Lung Diseases
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on November 20, 2014