Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients
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Purpose
Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).
| Condition | Intervention |
|---|---|
|
Dynamic Lung Hyperinflation COPD Patients Activities of Daily Livin. |
Other: Hyperinflation and ADL |
| Study Type: | Observational |
| Study Design: | Time Perspective: Cross-Sectional |
- Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients. [ Time Frame: 3 months ] [ Designated as safety issue: No ]
| Enrollment: | 19 |
| Study Start Date: | March 2007 |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| COPD hyperinflation |
Other: Hyperinflation and ADL
Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.
|
Eligibility| Ages Eligible for Study: | 50 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
The investigators included 19 COPD patients (13 male) with moderate to very severe degree of airway obstruction, with a mean post bronchodilator forced expiratory volume in the first second (FEV1) of 48.7 ± 7.1% predicted and mean age of 64.1 ± 5.3.
Inclusion Criteria:
- COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)
- clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form
Exclusion Criteria:
- Inability to perform the slow vital capacity maneuver
- excessive perceived dyspnea during the test
- arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation
Contacts and Locations More Information
No publications provided
| Responsible Party: | Antonio A.M. Castro, Dr., Federal University of São Paulo |
| ClinicalTrials.gov Identifier: | NCT01475812 History of Changes |
| Other Study ID Numbers: | 0353/03 |
| Study First Received: | November 17, 2011 |
| Last Updated: | November 18, 2011 |
| Health Authority: | Brazil: National Committee of Ethics in Research |
Keywords provided by Federal University of São Paulo:
|
COPD activities of daily living pulmonary hyperinflation exercise |
Additional relevant MeSH terms:
|
Lung Diseases Pulmonary Disease, Chronic Obstructive Lung Diseases, Obstructive Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on May 19, 2013